Identifying delirium in Parkinson’s: evaluation of existing tools and measures
Objective: To evaluate the diagnostic accuracy of tools to identify delirium in inpatients with Parkinson’s disease (PD). Background: Delirium is a serious acute state of…Deep brain stimulation and fusion technologies: a synthesis study
Objective: The major thrust is analyzing the large amounts data computationally generated and synthesizing it into useful systems-wide models of biological processes. Background: It is…Using Long read sequencing to identify complex structural variants in PRKN-PD
Objective: Identify complex structural variants in PRKN gene from Parkinson’s disease patients. Background: PRKN is the most frequent causative gene in young onset Parkinson's disease…Randomized, waitlist-controlled trial of Karate Intervention to Change Kinematic Outcomes in PD (KICK OUT PD)
Objective: To test the adherence to and efficacy of twice-weekly karate classes for people with mild to moderate Parkinson’s Disease (PD) on quality of life…Pallidal or subthalamic DBS for advanced Parkinson’s disease in the era of high-resolution MRI
Objective: We aimed to assess outcome of GPi-DBS and STN-DBS implanted based on high-resolution MRI. Background: Both GPi-DBS and STN-DBS are effective for treatment of…Associations between non-motor symptoms and patient characteristics in Parkinson’s disease: A multicenter cross-sectional study
Objective: We aimed to investigate factors associated with non-motor symptoms (NMS) in Parkinson's disease (PD). Background: PD is characterized by a variety of NMS, such…Analysis of the therapeutic potential of IkT-148009 in Parkinson’s disease
Objective: To evaluate the therapeutic potential of the selective, brain penetrant c-Abl inhibitor IkT-148009 in mouse models of progressive PD and the safety and tolerability…Factors affecting adaptive deep brain stimulation (aDBS) indications in Parkinson’s disease
Objective: We investigated the factors affecting the indications and effectiveness of aDBS based on the correlation between self-recorded on/off-state and beta oscillations in Parkinson's disease…Is there a common structural network for stimulation-induced dysarthria in subthalamic and thalamic deep brain stimulation?
Objective: To identify a common structural network for stimulation-induced dysarthria (SID) in thalamic deep brain stimulation (DBS) and DBS of the Nucleus subthalamicus (STN). Background:…Differential Rab10 & Rab8A phosphorylation by LRRK2 variants G2019S & I1371V manifests differences in membrane fluidity & pathogenicity.
Objective: To evaluate the difference in substrate (Rab8A & Rab10) phosphorylation by LRRK2 variants G2019S & I1371V on membrane fluidity & pathogenicity. Background: LRRK2 is…
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