Medication Burden and Associated Challenges for People with Parkinson’s: A Survey of 359 UK Patients
Objective: To quantify medication burden among people with Parkinson’s disease (PD) and explore factors which contribute to medication experience in PD. Background: Individualised, complex medication…Telerehabilitation Versus Conventional Therapy in Parkinson’s Disease: Evidence from Randomized Controlled Trials
Objective: To compare the effects of telerehabilitation and conventional rehabilitation on motor function and quality of life (QoL) in patients with Parkinson’s disease (PD). Background:…Cerebellar Network Compensation in Parkinson’s Disease: Functional Connectivity Across Motor and Cognitive Circuits
Objective: To investigate whether alterations in cerebellar connectivity with cortical and basal ganglia networks in Parkinson’s disease (PD) represent compensatory network adaptations related to dopaminergic…Kinetic–rest tremor polarity for differentiating dystonic tremor and Parkinson’s disease
Objective: To characterize ordinal patterns of tremor amplitude across rest, postural, and kinetic conditions in dystonic tremor (DT) and Parkinson's disease (PD) using accelerometry, and…An Ongoing Phase 1/2, Multi-center, Open Label Study of NouvNeu001 for the Treatment of Advanced Parkinson’s Disease
Objective: This ongoing, phase 1/2, multi-center, open label study aims to evaluate the safety, tolerability, and efficacy of NouvNeu001 (NCT#06167681) for treating mid to late-stage…Seed Amplification Assay Is More Sensitive To Detecting α-Synuclein In Gut Biopsies Than Immunohistochemistry
Objective: Assess seed amplification assay (SAA) and immunohistochemistry (IHC) in peripheral gut mucosal biospecimens as PD diagnostics. Background: SAA detects misfolded alpha-synuclein (α-syn) aggregates across…Complete Resolution of Troublesome Dyskinesia in People With Advanced Parkinson’s Disease Treated With Foslevodopa/Foscarbidopa: Post Hoc Analysis From a 52-Week Phase 3 Trial
Objective: To evaluate the achievement of complete elimination of troublesome dyskinesia (TSD) and associated changes in Off time, motor aspects of experiences of daily living…Predictors of Clinical Progression Over a Decade in GBA1 versus LRRK2 Non-Manifesting Carriers
Objective: To determine whether presence of synucleinopathy and dopaminergic biomarkers, either alone or in combination, predict phenoconversion to Parkinson’s disease (PD) differentially in GBA versus…Robust Location-Agnostic Turn Speed Estimation to Ensure Consistent Remote Monitoring of Gait Impairment in Parkinson’s Disease
Objective: To determine if a novel, location-agnostic algorithm provides consistent turn-speed measures in people with Parkinson’s (PwP) across sternum, lower back, and thigh locations. Background:…Changing the ‘Game’: The Impact of ‘Serious Games’-based Cognitive Training on Cognitive Function in Parkinson’s Disease
Objective: We evaluated the impact of NeuroOrb, a novel, accessible “Serious Gaming” computerised cognitive training (CT) platform, on cognitive function, mood and quality of life…
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