Functional Activity of Apomorphine Relative to Dopamine at Dopamine Receptors: Findings from G Protein Coupled Receptor Biosensor Assays
Objective: Characterize the functional activity of apomorphine relative to dopamine using a modern panel of G protein-coupled receptor biosensor assays. Background: The structural similarity of…Establishing Clinical Education and Patient Support Programs for Continuous Subcutaneous Apomorphine Infusion (CSAI) in the United States
Objective: Establish an educational “Master Class” program to prepare health care providers (HCPs) for CSAI availability in the U.S. and develop educational support for people…Safety Profile of Opicapone in Elderly and Very Elderly Population
Objective: This study aimed to characterize the safety profile of opicapone (OPC) in the elderly and compare post-marketing safety between (A) very elderly patients (≥…Efficacy of LSVT-BIG Treatment Compared to Other Physiotherapy in Patients with Parkinson’s Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Objective: We aim is to assess the efficacy of Lee Silverman Voice Treatment-BIG therapy (LSVT-BIG) compared to other physiotherapy in patients with Parkinson's Disease (PwP).…Medication therapy in Parkinson’s disease patients: a cross-sectional study at the University Medical Center at Ho Chi Minh City, Vietnam
Objective: To determine the rate of drugs prescribed to treat Parkinson's disease motor symptoms, the rate of the types of drug combinations, and the frequency…Comprehensive Multi-Platform Proteomic Analysis Identifies Novel Biomarkers for Parkinson’s Disease Diagnosis and Progression Monitoring
Objective: To replicate existing and identify novel protein biomarkers for PD diagnosis and progression. Background: Parkinson's disease (PD) lacks reliable biomarkers for early diagnosis and…Staging Disease Progression from Prodromal to Overt Stage of Alpha-synucleinopathies
Objective: To compute a disease progression model of the prodromal to overt synucleinopathy continuum, usable at single subject level. Background: Progression milestones to stage patients…Parkinson’s disease Symptoms Mitigated by Photobiomodulation: The Potential of the Tryptophan Kynurenine Ratio as a Marker for Responsiveness to Therapy.
Objective: To determine the potential of the tryptophan:kynurenine ratio (trp/kyn) as a marker for the responsiveness of Parkinson’s symptoms to treatment by photobiomodulation Background: The…Real world application of alpha-synuclein skin biopsy in the diagnosis of synucleinopathies at a tertiary care center
Objective: The goal of this study is to review the real-world application of alpha-synuclein skin biopsy at a tertiary care center. Background: Synucleniopathies including Parkinson’s…Digital measurement of ocular microtremor in Parkinson’s Disease: Analytical and clinical validation
Objective: This pilot study examined the analytical and clinical validation of OMT measurement via the iTremor ONE device in PwPD. Background: Ocular microtremor (OMT) is…
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