Cardiovascular Autonomic Dysfunction and Cognitive Impairment in Parkinson’s Disease: A Systematic Review
Objective: To review evidence linking cardiovascular autonomic dysfunction with cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment is a frequent non-motor complication of PD…Vitamin D Status and Levodopa Responsiveness in Parkinson Disease and Association With Gastrointestinal Symptoms
Objective: To evaluate the association between serum vitamin D levels and clinical responsiveness to levodopa in patients with Parkinson disease and to explore potential relationships…The UF Adaptive Deep Brain Stimulation Experience
Objective: To describe our single center experience with implementing adaptive deep brain stimulation (aDBS) strategies into a high-volume neuromodulation center. Background: Adaptive deep brain stimulation…Allogeneic iPSC-Derived Dopaminergic Progenitor Transplantation for Parkinson’s Disease: A Phase 1, Dose-Escalation Trial
Objective: To evaluate the safety, tolerability, and preliminary efficacy of putaminal implantation of XS411 (allogeneic iPSC-derived dopaminergic progenitors) in advanced PD (NCT07080775). Background: Parkinson’s disease (PD)…smSAA: developing a quantitative seed amplification assay with single molecule spectroscopy
Objective: Alpha-synuclein seed amplification assays (SAA) are highly sensitive and specific for detecting endogenous alpha-synuclein (Syn) seeds and are emerging as diagnostic tools for early…Seeing the Full Picture: How Subjective and Objective Data Capture the Daily Impact of Fluctuations in Parkinson’s disease.
Objective: To characterize the frequency, phenomenology, subjective relevance, and daily life impact of motor and non-motor fluctuations in a multicenter cohort of Parkinson’s disease (PD)…Feasibility study of a portable medical device, the Neuromotor pen, as a screening tool for Parkinson’s disease in a rural northern Tanzania
Objective: To evaluate the feasibility and acceptability of the Neuromotor pen (NMP) as a screening tool for Parkinson’s disease in a rural Tanzanian population. Background:…Peripheral Inflammatory Markers and Clinical Correlations in Parkinson’s Disease Patients Carrying LRRK2 G2385R and R1628P Variants
Objective: To investigate plasma cytokines and chemokines with clinical correlations between Parkinson’s disease (PD) patients carrying LRRK2 p.G2385R and/or p.R1628P variants, idiopathic PD (iPD), and healthy controls.…Levels of cytokines in the cerebrospinal fluid of patients depending on the stages of Parkinson’s disease
Objective: To study of cytokine levels in serum and cerebrospinal fluid of patients with different stages of PD. Background: The clinical course of Parkinson's disease…Altered Diet–Microbiome Associations in Parkinson’s Disease and Prodromal REM Sleep Behavior Disorder
Objective: To investigate whether disease-related microbial dysbiosis modifies the relationship between dietary intake and gut microbiome composition and function in Parkinson’s disease (PD) and idiopathic…
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