Association between severity of freezing of gait and turning characteristics in Parkinson’s disease
Objective: To investigate the turning characteristics of people with Parkinson’s disease (PD) with freezing of gait (FoG) according to the turning direction. Background: For people…The induction of mitochondrial damage by alpha synuclein In Parkinson’s disease.
Objective: Alpha synuclein aggregation have been indicted in the process of neuronal cell loss in Parkinson's disease; however, there have been several hypothesis to explain…Efficacy and safety of adjunctive oral therapy in Parkinson’s disease with motor complications: a systematic review and network meta-analysis
Objective: To review the evidence and compare the efficacy and safety of catechol-O-methyltransferase inhibitors (COMT-Is), dopamine agonists (DAs) and monoamine-oxidase B inhibitors (MAOB-Is) as adjunctive…Microstructural abnormalities of the dentato-rubro thalamo-cortical tract in tremor dominant PD and ET plus syndrome: A DTI, NODDI and free water-based analysis
Objective: To evaluate microstructural integrity of the dentato-rubro thalamo-cortical tract (DRTT) in tremor dominant Parkinson’s disease (TDPD) and ET plus (ETP) syndrome using a multimodal…Disease progression of data-driven subtypes of Parkinson Disease (PD): 5-year longitudinal study from The Early Parkinson’s disease Longitudinal Singapore (PALS) cohort
Objective: To evaluate the non-motor symptom(NMS), motor and cognition progression among the Parkinson Disease (PD) clusters derived from data-driven approach. Background: Data-driven PD subtypes were…Disruption of Locus Coeruleus-Related Functional Networks in Parkinson’s Disease
Objective: We used resting-state functional MRI (rs-fMRI) to investigate the alterations of functional connectivity (FC) of LC-related resting-state networks (RSNs) and the associations between RSNs…Serum Zinc Deficiency could be associated with dementia conversion in Parkinson’s disease
Objective: To investigate the role of depletion or excess of various heavy metals on clinical characteristics of Parkinson's disease (PD) developing PD dementia in drug-naïve…Quantifying the value of multimodal MRI in outcomes prediction for STN DBS in PD
Objective: To compare the predictive value for motor outcomes of multimodal MRI to clinical predictors alone in STN DBS for PD. Background: STN DBS is…Investigating glutamate toxicity associated to Park2 mutations in pre-clinical models of Parkinson’s Disease
Objective: To generate and characterize induced pluripotent stem cells (iPSCs)-derived in vitro cellular models of Autosomal Recessive Juvenile Parkinsonism (ARJP) carrying Park2 mutations with a…Beyond Parkinson´s disease and synucleinopathies: unexpected identification of prodromal corticobasal syndrome by the updated MDS research criteria for prodromal PD
Objective: The aim of the current study was to determine the proportion of patients, initially classified as having prodromal Parkinson’s disease (pPD), phenoconverted to manifest…
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