Intersectin-1 (ITSN1) Loss-of-Function Variants in Parkinson’s Disease: Clinical Phenotypes and Neuropathological Insights
Objective: To examine the clinical and neuropathological features of carriers of loss-of-function (LoF) variants in ITSN1. Background: Intersectin-1 (ITSN1) is a large multidomain protein involved…Sleep Patterns and Cognitive Function in Parkinson’s Disease: a Longitudinal Pilot Study
Objective: To evaluate the feasibility and usability of a commercially available wearable device for long-term monitoring of sleep patterns in Parkinson’s disease (PD) and how…Brain-First and Body-First Model Translated to Individual-Level Characterization in Parkinson’s Disease: Multimodal Imaging and Clinical Approach
Objective: To determine whether the body-first versus brain-first hypothesis of Parkinson’s disease (PD) can be reliably applied at the individual patient level using multimodal clinical…Caffeine and Tobacco Exposure and the Presence of Levodopa-Induced Dyskinesia (LID) in the STAT-PD Trial
Objective: Using data from the STAT-PD trial, ClinicalTrials NCT # 4064294, we examined whether lifetime caffeine and nicotine exposure are associated with the presence and…Interleaving Deep Brain Stimulation: Achieving Optimal Clinical Outcomes at Lower Per-contact Voltages and Energy Consumption
Objective: - Background: The goal of deep brain stimulation (DBS) is to achieve optimal symptom control while minimizing stimulation-related side effects. Interleaving stimulation offers a…Volumetric Imaging Diagnostic Tool to Differentiate Progressive Supranuclear Palsy from Parkinson’s Disease using Artificial Intelligence
Objective: To develop and evaluate a novel MRI-based volumetric diagnostic index using artificial intelligence–driven segmentation for differentiating progressive supranuclear palsy (PSP) from Parkinson’s disease (PD).…Neuropsychiatric Symptoms in Parkinson’s Disease in Low- and Middle-Income Countries: A Systematic Review
Objective: To assess the prevalence and patterns of neuropsychiatric symptoms among patients with Parkinson’s disease in low- and middle-income countries (LMICs). Background: Neuropsychiatric manifestations such…Analyzing Perceived Effectiveness of Implemented Recruitment and Retention Strategies for Underrepresented Racial and Ethnic Groups in Parkinson’s Disease Clinical Trials
Objective: To analyze racial and ethnic disparities and to identify perceived effective strategies for patient recruitment and retention at Parkinson Study Group (PSG) sites. Background:…Divergent Glymphatic Dysfunction and Free Water Pathology Underpin Distinct Mechanisms and Enable Differential Diagnosis in Parkinson’s Disease and Multiple System Atrophy
Objective: To evaluate glymphatic function and FW pathology in PD and MSA, and to develop an integrated biomarker panel for differential diagnosis. Background: Parkinson's disease…Proteomics Reveals Sex- and Age-of-onset-Stratified Immune Dysregulations in Parkinson’s Disease
Objective: Employing a proteomics approach, this study aimed to profile immune dysregulation signatures in male and female Parkinson’s disease (PD) patients, as well as in early-onset…
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