Intestinal Levodopa Infusion Therapies in Advanced Parkinson’s Disease: A 6-Month Prospective Cohort Study
Objective: To evaluate 6-month changes in motor and non-motor outcomes in patients with advanced Parkinson’s disease treated with levodopa/carbidopa intestinal gel (LCIG) or levodopa/entacapone/carbidopa intestinal…Single-Cell Transcriptomics and Experimental Models Implicate Functional Hypoxia in Microglial DAM Polarization and α-Synuclein Accumulation, with Involvement of HIF-1α, in Parkinson’s Disease
Objective: To investigate whether microcirculatory impairment-induced hypoxia contributes to the emergence of a late-stage disease-associated microglia (DAM) phenotype and impaired α-synuclein clearance in Parkinson's disease…Real-World Mobility Measures Reveal Early Indicators of Parkinson’s Disease Risk in Older Women
Objective: To evaluate cost-effective, interpretable methods for identifying elevated risk for Parkinson’s disease using real-world wearable accelerometry and self-reported health data. Background: Mobility changes may emerge…Genetic Modifiers of Age at Onset for Parkinson’s Disease in European Populations
Objective: To investigate genetic factors underlying age at onset (AAO) variability in PD in the largest diverse European cohort to date. Background: Genetic factors substantially…Digital Kinematic Measures of Finger Tapping Detect Dose-Dependent Effects of Deep Brain Stimulation in Parkinson’s Disease
Objective: To evaluate whether video-based digital kinematic measures can quantify dose-dependent changes in finger tapping performance during deep brain stimulation (DBS) in Parkinson’s disease. Background:…Clinical Features of DJ1 Gene Mutation Causing Parkinson’s Disease from a Single Centre
Objective: Describe the detailed clinical characteristics of patients diagnosed with Parkinson’s disease (PD) who have the DJ1 gene mutation. Background: Inherited PD represents 5-10% of…Sex-Specific Differences in Parkinson’s Disease: A Retrospective Analysis of over 10,000 Patients from the Paracelsus-Elena Hospital, a Specialized Movement Disorder Clinic in Germany
Objective: To analyze sex differences in PD in a large cohort from a hospital specializing in PD and other movement disorders. Background: Sex differences in…A Specialized 3D-Printed Device for Gait Rehabilitation in Parkinson’s: Development and Application.
Objective: To develop and evaluate the efficacy of a specialized 3D-printed device designed to correct gait disorders in Parkinson's disease by enhancing step initiation via…Levels of IgA and IgG concentrations by stage of Parkinson’s disease
Objective: To study of IgA and IgG levels cerebrospinal fluid of patients with different stages of PD. Background: In the clinical course of Parkinson's disease…Substantia nigra neuromelanin magnetic resonance imaging in LRRK2 asymptomatic carriers
Objective: To investigate SN Neuromelanin in asymptomatic LRRK2 carriers. Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with long pre-clinical and prodromal stages. The…
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