GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase show evidence of pharmacological efficacy in conduritol β-epoxide (CBE) models of Parkinson’s disease
Objective: Demonstrate the involvement of our structurally targeted allosteric regulator Parkinson’s disease (PD) candidate, GT-02287, in decreasing the CBE-induced neurotoxic effect and in restoring lysosomal…Programming algorithm for the management of speech impairment in STN-DBS for Parkinson’s disease
Objective: To establish an evidence- and experience-based algorithm for the management of speech impairment (SI) in Parkinson’s disease (PD) patients treated with STN-DBS. Background: STN-DBS…Unraveling the Potential of Specialized Allied Health Therapy in Parkinson’s Disease
Objective: To investigate discipline-specific effects of specialized Allied Health Therapy on the incidence of Parkinson’s Disease (PD)-related complications. Background: Specialized physiotherapy has been shown to…Psychiatric evaluation according to Brief Psychiatric Rating Scale-Expanded in patients with Parkinson’s disease
Objective: The aim of the study was to evaluate psychiatric manifestations of Parkinson’s disease (PD) and to establish statistical links with sociodemographic and clinical PD…Temporal dynamics and longitudinal predictors of apathy in Parkinson’s disease
Objective: To determine how apathy varies across different disease stages of Parkinson’s disease (PD) and the longitudinal predictors of its development, using a large PD…Silencing dopamine neurons during sleep slows disease progression in parkinsonian mice
Objective: To develop a treatment to stop or slow the progression of Parkinson's disease. Background: Parkinson’s disease (PD) is believed to be caused by the…Amantadine Is Effective Long-term in Parkinson’s Disease
Objective: This study aimed to investigate the long-term effectiveness of amantadine in patients with PD. Background: Amantadine has been used in the symptomatic treatment of…CLINICAL CORRELATION OF VISUAL LEUKOARAIOSIS SCALES AND VOLUMETRIC ANALYSIS IN PATIENTS WITH ISCHEMIC CEREBRAL VASCULAR EVENT AND PARKINSON’S DISEASE.
Objective: Search for the clinical correlation of the most used leukoaraiosis scales in Parkinson's disease and ischemic stroke. Background: In recent decades, there has been…The shaky truth of a Movement Disorder Nurse pilot program in Rural Australia
Objective: The conception of the Movement Disorder Nurse program began when the Australian Government and Fight Parkinson’s conducted a scoping evaluation of people living with…SCFAs participate in the pathogenesis of Parkinson’s disease by regulating NLRP3 inflammasomes activation
Objective: To explore the role and related mechanism of gut microbiota metabolites short-chain fatty acids(SCFAs) in the pathogenesis of Parkinson's disease(PD). Background: Growing research have…
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