Intestinal microbial dysbiosis promotes prebiotic-reversible inflammation in Parkinson’s disease
Objective: To determine the functional effects of disrupted intestinal microbiota in Parkinson’s disease (PD), particularly the impacts of dysbiosis on inflammation, neuroprotective hormone secretion, and…Design of the Remote Optimization Adjustment and Measurement for Deep Brain Stimulation (ROAM-DBS) Randomized Controlled Trial Using Decentralized Patient Monitoring
Objective: To describe the design of the ROAM-DBS trial which measures outcomes of remote programming using remote monitoring. Background: A third of Parkinson’s Disease (PD)…‘Top of the POPPS’ – how we set up an online support group for Partners of People with Parkinson’s.
Objective: To provide useful peer and professional support for partners of people with Parkinson's (PWP)To be able to offer that support in a Covid safe…A qualitative study exploring the treatment burden and capacity of people with Parkinson’s and their caregivers
Objective: To explore experiences of treatment burden and capacity in Parkinson’s and identify potentially modifiable factors that can improve this Background: Treatment burden, the workload…Lymphocyte count/neutrophil-to-lymphocyte ratio and mild cognitive impairment in Parkinson’s disease
Objective: The present study aimed to elucidate whether i) lymphocyte count and neutrophil-to-lymphocyte ratio (NLR) can discriminate Parkinson's disease (PD) patients from healthy controls (HC);…Developing zebrafish CRISPR/Cas9 knockout models of Parkinson’s Disease to identify novel therapeutic targets.
Objective: Human patients present punctual mutations and/or small deletions in genes that have been associated with Parkinson’s disease, namely, park1, park2, park6, park7, and park8.…No evidence for the impact of SNCA rs356219 on Parkinson’s disease progression
Objective: To replicate findings from previous studies reporting an association between the α-synuclein (SNCA) rs356219 genetic variant and progression to key outcomes in Parkinson’s disease…Real-World Deep Brain Stimulation Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control
Objective: We report clinical outcomes associated with the use of Deep Brain Stimulation (DBS) systems capable of directionality and Multiple Independent Current Control (MICC). Background:…Imaging progressive peripheral and central dysfunction in isolated REM sleep behaviour disorder after 3 years of follow-up
Objective: To image progression of intestinal dysfunction, cardiac sympathetic denervation, and dopaminergic nigrostriatal damage in patients with isolated REM sleep behaviour disorder (iRBD). Background: A…Measuring what matters in Parkinson’s disease – validating real-world digital mobility outcomes for widespread adoption
Objective: To validate and support widespread adoption of real-world digital mobility outcomes (DMOs) to monitor mobility performance, disease progression and predict falls in patients with…
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