MR guided high-intensity ultrasound thalamotomy in essential tremor and Parkinson´s disease: is there an ideal candidate?
Objective: To report the efficacy and safety of unilateral thalamotomy at Ventralis intermediate nucleus (VIM) by MR guided High-Intensity Focused Ultrasound (MRgHIFU) in treatment of…Supervised, home-based, real-time videoconferencing telerehabilitation preserves perception of some clinical aspects in people with Parkinson’s disease: preliminary data of a retrospective study
Objective: To compare retrospectively the effects of 10 months of supervised, home-based, real-time videoconferencing telerehabilitation (RTT) and usual care without exercise training (UC) on self-reported…Parkinson’s Disease Clinical Progression in Latino Patients
Objective: To compare clinical progression of PD in Latino and White Non-Latino (WNL) patients enrolled in a community-based study, exploring potential disparities and what might…Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism
Objective: We set out to compare patterns of dyskinetic behaviours induced by the systemic administration of L-DOPA and D1 or D2 receptor (D1R, D2R) agonists…Analysis of handgrip strength, upper limb traction and ground reaction force on bus step climb in healthy elderly subjects and individuals with Parkinson’s disease
Objective: To analyze and compare the strength hand, upper limbs traction strength and the ground reaction force (FRS) during step up in a bus, in…Efficacy of opicapone according to levodopa’s duration of use in Parkinson’s disease patients with motor fluctuations
Objective: To evaluate the efficacy of opicapone (OPC) in Parkinson’s disease (PD) patients with motor fluctuation (MF) according to levodopa’s duration of use. Background: OPC…The ADOPTION (eArly levoDopa with Opicapone in Parkinson’s paTients wIth motOr fluctuatioNs) study in Parkinson’s disease: design and rationale of a randomized prospective, open-label exploratory trial
Objective: This study aims to explore the potential of opicapone (OPC) to optimize levodopa (L-dopa)/dopa decarboxylase inhibitor (DDCi) as first-line approach to treat wearing-off in…OPTI-ON: A Longitudinal Real-World Study of Opicapone in Patients with Parkinson’s Disease and Motor Fluctuations
Objective: To conduct a longitudinal real-world study that examines treatment patterns, clinical outcomes, safety and tolerability of opicapone as an adjunctive treatment to carbidopa/levodopa (CD/LD)…Subcutaneous Levodopa Infusion for Parkinson’s disease Patients with Motor Fluctuations: Open-Label Efficacy Outcomes from the BeyoND study
Objective: To review one-year exploratory efficacy data from the ND0612 BeyoND study. Background: ND0612 is an investigational subcutaneous delivery system providing minimally invasive, continuous infusion…The mitochondrial targeted drug SBT-272 attenuates dopaminergic neuron loss, alpha-synuclein burden and neuroinflammation in a mouse model of Parkinson’s Disease
Objective: To assess the preclinical efficacy of the investigational drug SBT-272 in a mouse model of Parkinson’s Disease (PD). Background: SBT-272 is a peptidomimetic drug…
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