PD Similarity Index: A Wearable Gait Biomarker Capturing the Continuum from iRBD to Parkinson Disease
Objective: To evaluate a wearable IMU-derived PD Similarity Index (PSI), a continuous monotonic score designed to position individuals along the spectrum from healthy controls (HC)…Dopamine depletion does not mitigate striatal reward prediction error signals
Objective: To elucidate the role of dopamine in computing reward prediction error signals in the basal ganglia Background: Phasic discharges of midbrain dopamine neurons are…High-dimensional proteomic profiling in plasma and CSF identifies molecular signatures in Parkinson’s disease
Objective: To characterise Parkinson’s disease (PD)-related proteomic profiles in plasma and cerebrospinal fluid (CSF), to assess differential expression between PD and healthy controls (HC), along…Motor and Non-Motor Symptoms Across Psychiatric Profiles in Parkinson’s: A Cluster Analysis
Objective: To compare the differences in motor and non-motor symptoms assessed with the Movement Disorders Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) among the different…Toxic narratives: Farmers with Parkinson’s Disease in the foothills of Kilimanjaro
Objective: To investigate the toxicological and epidemiologic perspective on pesticide exposure in Parkinson’s Disease in an exceptional region. Background: In most lower income countries (LIC)…Genome-wide Discovery of Genetic Modifiers of LRRK2 risk in Parkinson’s Disease Carriers across European Populations
Objective: To identify genetic risk modifiers for LRRK2 variant carriers of European ancestry. Background: The LRRK2 p.G2019S variant is associated with substantially elevated risk for…Pain Assessment using Parkinson’s Disease Pain Classification System (PD-PCS) and King’s Parkinson Disease Pain Scale (KPPS) – a Comparative Study
Objective: To evaluate and compare the applicability of KPPS and the PD-PCS in patients with Parkinson’s disease Background: Pain assessment in PD remains a relevant…Treatment Patterns in Parkinson’s Disease in Kyrgyzstan: Evidence from a Kyrgyz PD Cohort
Objective: To characterize treatment patterns and access to antiparkinsonian medications among patients with Parkinson’s disease (PD) in Kyrgyzstan. Background: Access to treatment for PD remains…Cholinergic dysfunction associated to aberrant functional connectivity in Parkinson Disease-related dystonia
Objective: Assess presynaptic cholinergic integrity and associated functional connectivity differences in Parkinson disease (PD)-related dystonia. Background: Dystonia is observed in 30-60% of individuals with PD.…Correlations Between Clinical Variables And Cerebral Perfusion in Parkinson’s Disease With Mild Cognitive Impairment: A Multi-Delay pcASL Study
Objective: To evaluate whether partial volume–corrected cerebral blood flow (pvCBF), with and without additional spatial smoothing (5 mm), improves detection of perfusion differences and clinical…
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