Levodopa dosing regimen influences repetitive tongue force maintenance in Parkinson’s disease
Objective: To investigate whether levodopa (LD) dosing regimen influences the dynamics of repetitive maximal tongue pressure (MTP) in patients with Parkinson’s disease (PD). Background: Reduced…Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…Ecological Momentary Assessment Monitoring Captures Motor Fluctuation Improvement after DBS in Parkinson’s Disease
Objective: To evaluate whether mobility measures based on ecological momentary assessment (EMAs) capture deep brain stimulation (DBS) motor improvement in Parkinson’s disease (PD) and correlate with clinician-rated motor impairment (UPDRS III) and motor…Quantitative Changes in Speech After Focused Ultrasound Subthalamotomy and Thalamotomy in Parkinson’s Disease
Objective: To assess speech outcomes in Parkinson’s disease (PD) patients following unilateral MR-guided focused ultrasound (MRgFUS) targeting the subthalamic nucleus (STN) and ventral intermediate nucleus…Lysosomal polygenic risk score in Parkinson disease across populations.
Objective: (1) Evaluation of lyso-PRS performance for PD status across diverse populations; (2) Comparison of the lyso-PRS across idiopathic PD (iPD), GBA1-PD, non-manifesting GBA1 carriers…Markerless Kinematics of Levodopa Response During Activities of Daily Living in Parkinson’s Disease
Objective: To determine whether markerless motion tracking during activities of daily living (ADLs) can identify kinematic changes during medication wearing-off as Parkinson's disease (PD) patients…Examining the Impact of Fatigue on White Matter tracts in Parkinson’s Disease
Objective: To determine whether people with Parkinson’s disease (PwPD) with fatigue, and those without fatigue, experience differences in white matter structural connectivity (SC). Background: Fatigue…Spiritual Well-Being and Clinical Burden in Parkinson’s Disease: A Case–Control Study
Objective: To investigate spiritual well-being in patients with PD compared with healthy controls and to examine its relationship with motor symptoms, non-motor burden, and health-related…Rehabilitation Following Initiation of Device Assisted Treatment in Parkinson’s Disease – a Randomized Controlled Trial
Objective: To investigate if coordinated rehabilitation after starting Device Assisted Treatment (DAT) improves daily activity performance/skills, participation, and disease specific quality of life. Background: DATs…How large must a Parkinson’s disease trial be to detect pharmacogenomic interactions? Power benchmarks derived from the Exenatide PD3 clinical trial
Objective: To investigate whether genetic variation in the GLP1R gene modifies treatment response to the GLP1 agonist exenatide in the Exenatide-PD3 trial, and to characterise…
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