VPS35-Related Parkinson Disease in a Patient of Korean Ancestry: A Case Report
Objective: To report a case of a 65-year-old Korean woman diagnosed with a rare gene mutation involving VPS35 linked to Parkinson’s disease (PD). Background: Major…Utilizing the Global Parkinson’s Genetics Program (GP2) to develop a precision medicine recruitment protocol
Objective: Can the Global Parkinson’s Genetics Program (GP2, http://gp2.org/) leverage its rich data and connectivity to address the growing issue of identifying individuals that can…Association of sequence alterations in the promoter region of the RAB7L1 gene with lysosomal hydrolase activity in blood and reduced risk of Parkinson disease
Objective: The aim of this case-control study was to examine the association between SNPs located in the promoter region of the RAB7L1 gene and Parkinson's…Subthalamic Nucleus Stimulation May Suppress Both Ipsilateral and Contralateral Local-Field-Potential Magnitude
Objective: Determine whether ipsilateral subthalamic nucleus (STN) stimulation affects local field potential (LFP) power in the contralateral STN to inform clinical decision making. Background: A…Initial Experience with a Crossover Study Comparing Automated Connectomic Programming to Standard Clinical Programming for DBS
Objective: To compare the efficacy of a novel automated connectomic programming (ACP) algorithm to standard clinical programming (SCP) in patients undergoing deep brain stimulation (DBS)…A Retrospective, Multicenter, Harmonized Data Collection for Uncovering DBS Long-Term Axial Response
Objective: To determine pre-surgery (e.g., motor phenotype), during-surgery (e.g., electrodes' position), and post-surgery (e.g., stimulation parameters) factors predicting DBS-induced effects on axial symptoms in people…From Campotomy to MR-Guided Focused Ultrasound Pallidothalamic Tractotomy for Parkinson’s: A Systematic Review in the Context of a Phase III Study
Objective: To summarize and review efficacy and safety evidence of pallidothalamic tractotomy (PTT) using MR-guided focused ultrasound (MRgFUS). Background: Speigel and Wycis performed lesions in…Weight loss post deep brain stimulation to bilateral subthalamic nuclei in a Parkinson’s disease with PARKIN mutation – A Harbinger sign of malignancy
Objective: We present a challenging case of genetic PD who presented with progressive weight loss and constipation despite post-DBS and was found to have malignancy.…Application of Respiratory-Controlled Cardiopulmonary Coupling in Early Diagnosis of Parkinson’s Disease
Objective: Studies have shown that autonomic nervous symptoms precede motor symptoms in PD, making autonomic function assessment a potential tool for early PD diagnosis. This…Exploring the Trade-offs Between Speech and Gait in Parkinson’s Disease
Objective: The goal of the study was to explore speech and gait performance trade-off when individuals with Parkinson’s disease (PD) engaged in concurrent speaking and…
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