Environmental Risk Factor Co-Exposure as Drivers of Parkinson’s Disease Development: A Scoping Review
Objective: To map and synthesise epidemiological evidence assessing environmental co-exposures and Parkinson’s disease (PD) risk Background: PD is a multifactorial neurodegenerative disorder attributed to genetic,…Distinct Local and Global Functional Network Reorganization Underlying STN versus GPi DBS in Parkinson’s Disease
Objective: To identify target-specific neuroimaging biomarkers for STN and GPi DBS and evaluate their impact on the global functional hierarchy and clinical outcomes. Background: Selection…Quantitative Susceptibility Mapping Revealed Regional Iron Alteration and As a Biomarker for Dopaminergic Deficits in Parkinson’s Disease
Objective: This study aimed to identify regions with altered brain iron accumulation using quantitative susceptibility mapping (QSM) and to investigate the association between iron deposition…LRRK2 in Focus: A Global Browser Linking Genetic Diversity to Functional Effects
Objective: To develop a publicly accessible web browser that allows users to easily explore the distribution of LRRK2 variants in both Parkinson’s disease (PD) and…Voice-Based Screening of Parkinsonian Disorders Using Acoustic Feature Analysis and Machine Learning
Objective: To evaluate whether acoustic features from voice recordings can distinguish Parkinson’s disease and related parkinsonian disorders from healthy controls. Background: Speech production depends on…Clinical Underestimation of Wearing-Off in Parkinson’s Disease: Patient-Reported Outcomes Versus Clinical Assessment and Impact on Quality of Life
Objective: To prospectively investigate the frequency and determinants of wearing-off (WO) in Parkinson's disease (PD) using a validated patient-reported instrument compared to routine neurological evaluation,…Occupational Pesticide Exposure, Personal Protective Equipment, and Parkinson’s Disease: An Observational Study from the PPMI Cohort
Objective: To evaluate the association between occupational exposure to specific pesticides and Parkinson’s disease in participants from the PPMI Online cohort, and to determine whether…Beyond Motor Symptoms: Utilizing the FreeSurfer Brainstem Substructures Module to Characterize a Complex Parkinsonian Phenotype with Profound Dysautonomia
Objective: To describe the autonomic function profile and quantitative brainstem substructures analysis in a 62-year-old male of Parkinsonism complicated by severe autonomic failure and neuropsychiatric…Genome-wide Discovery of GBA1 Modifiers in Parkinsons Disease Carriers across Populations from the Global Parkinsons Genetics Program
Objective: To identify genetic risk modifiers for GBA1 risk variant carriers of European and African ancestry, we used data from GP2 (http://gp2.org/), the UK Biobank,…Bridging Genetics and Precision Medicine in Parkinson’s Disease through GP2: Translating Genetic Risk into Trial-Eligible GBA1 and LRRK2 Cohorts
Objective: To advance precision medicine in Parkinson’s disease (PD) by integrating large-scale clinico-genetic data from diverse populations worldwide and establishing a framework to characterize individuals…
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