Unraveling the Intertwined Relationship of DBS, Parkinson’s Disease Subtype and LEDD: A Retrospective Study
Objective: To assess the impact of deep brain stimulation (DBS) target and Parkinson’s disease (PD) motor subtype on the total levodopa equivalent daily dose (LEDD)…Therapeutic Potential of GLP-1 Receptor Agonists in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess the safety and effectiveness of GLP-1 RAs in patients with PD. Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by…Individual physiomarkers of levodopa-induced local field potential fluctuations interact with deep brain stimulation in Parkinson’s disease
Objective: We investigated the behavior of LFPs in 57 patients across therapeutic states using a data-driven method to find personalized physiomarkers. Background: The power of…Phase 1 and 1b Pharmacodynamic Data Support Central Modulation of Lysosomal Pathways With BIIB122/DNL151, a LRRK2 Kinase Inhibitor: Insights for the LUMA Trial
Objective: Evaluate the effects of BIIB122/DNL151 treatment on CSF levels of pRab10, a biomarker of CNS LRRK2 modulation, in a Phase 1 study in healthy…Identification of Rigidity in Parkinson’s Disease Using Wearable Technology
Objective: To evaluate the capacity of upper limb kinematic measures, collected using wearable technology, in (a) capturing clinical rigidity in Parkinson’s disease (PD) and (b)…1H-NMR and UPLC/MS Metabolomics Identify Disrupted Homeostasis of Energy, Amino Acids, and Glutathione Metabolism as Serum Signatures in Parkinson’s Disease Patients
Objective: We sought to identify a signature distinctive of Parkinson’s disease (PD) through two independent metabolomics approaches. Background: A recent meta-analysis showed a considerable inconsistency…Interpretable voice-based detection of Parkinson’s disease using language-independent graph neural networks
Objective: To develop a robust, interpretable, and language-independent tool for voice-based detection of Parkinson’s disease (PD) using graph neural networks (GNNs), demonstrating superior cross-linguistic generalization…Evaluation Of Visual Perception Using Noise Pareidolia Test in Bangladeshi Patients with Parkinson’s disease.
Objective: To evaluate the prevalence of visual misperception in patients with PD (PwP) in comparison with healthy control (HC) and its association with visual hallucinations.…Ameliorating effect of linalool on anxiety disorders in Parkinson’s mice and related mechanisms
Objective: The aim of this study was to verify the ameliorating effect of linalool（LIN） on anxiety-related affective disorders and the associated receptors in a MPTP…Caution in the creation of Parkinson’s disease cognitive composites
Objective: To evaluate the structural validity of new cognitive composites in Parkinson’s disease (PCCs). Background: PCCs created from constituent tasks are promising in their single-index…
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