Phenoconversion from Rapid Eye Movement Sleep Behavior Disorder to Parkinson’s Disease: A multimodal Imaging Study
Objective: To elucidate the pathological progression from rapid eye movement sleep behavior disorder (RBD) to Parkinson’s disease (PD), we investigated tissue-level neurodegenerative changes using multimodal…Electrophysiological Evaluation of Visual Hallucination in Parkinson’s Disease Psychosis
Objective: Our understanding of the psychosis in Parkinson’s disease (PDPsy) is incomplete, and standard of care treatment with antipsychotics has its limitations. Neuroimaging and histopathology in PDPsy reveal that visual hallucinations (VHs), the hallmark of psychosis in PDPsy, arise…Parkinson’s Disease Duration at Total Knee Arthroplasty and 5-Year Vascular and Periprosthetic Outcomes: A Nationwide Matched Cohort Study
Objective: The objective of the study was to evaluate whether Parkinson's disease (PD) is associated with long-term risks of vascular events (cardiovascular and cerebrovascular) and…Considering Oral Health to Optimise the Potential for Current and Future Treatments in Parkinson’s Disease
Objective: To determine if the Oral Health Assessment Questionnaire (OHAQ) devised by 2 Parkinson’s Disease Nurse Advanced Practitioners (PDNAP) could facilitate a healthier mouth to…DTI-ALPS index and its association with dopamine loss, brain metabolism, and motor and cognitive manifestations in Parkinson’s disease
Objective: This study aimed to investigate the clinical relevance of glymphatic dysfunction in Parkinson's disease (PD) by integrating the diffusion tensor imaging (DTI) analysis along…Neuroinflammation and neurodegeneration biomarkers in Parkinson’s disease: integration of neuroimaging and fluid markers
Objective: To investigate the association between serum and cerebrospinal fluid (CSF) levels of NfL and GFAP and dopaminergic degeneration measured by 123I-ioflupane SPECT (DaTSCAN) in…Clinical and Genetic Profile of the ACTIVATE Population: A Phase 2 Trial of BIA 28-6156 in GBA-PD
Objective: To characterize the patient population enrolled in the ACTIVATE study, a Phase 2 multicenter, randomized, double-blind, placebo-controlled trial assessing the efficacy, safety, tolerability, pharmacodynamics,…External Validation of a Machine Learning Classifier for Motor Progression in Parkinson’s Disease
Objective: To externally validate a previously published machine learning (ML) classifier for predicting motor symptom progression in Parkinson’s disease (PD) using an independent clinical dataset.…5-year Longitudinal Changes in Non-motor Symptoms and Their Association With Motor Progression in Parkinson’s Disease
Objective: To examine longitudinal relationships between non-motor symptoms (NMS) and motor progression in Parkinson’s disease (PD), and to determine whether baseline NMS predict motor decline…Clinical feasibility of a semi-automated Olfactometry System in α-Synucleinopathies
Objective: To evaluate the feasibility, performance, and diagnostic accuracy of a semi-automated olfactometry system (NOS-DX1000) for standardized assessment of olfactory dysfunction in α-synucleinopathies. Background: Olfactory…
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