Spatial Metabolic Covariance Networks in PSP: Implications for Symptomatology and their Neural Basis
Objective: This study aimed to apply spatial ICA to 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) data from PSP patients and healthy controls (HCs) to identify…Asymptomatic GBA1 Mutation Carriers Have Increased Cortical Cholinergic Activity
Objective: The objective of this study was to assess cholinergic activity changes in patients with Parkinson’s disease carrying GBA1 variants(GBA-PD) and in non-manifesting carriers(GBA-NMC) using…Brain Target Engagement and Pharmacokinetic-Enzyme Occupancy (PK-EO) Relationship of FNP-223: A Novel Oral OGA Inhibitor for Progressive Supranuclear Palsy – Phase 1 PET Study
Objective: To determine the brain O-GlcNAcase (OGA) occupancy, following a single oral dose of FNP-223 (formerly ASN90) and to determine PK-EO relationship. Background: Preclinical evidence…STN-DBS Improves Motor and Cognitive Functions Associated with Increased Occipital Metabolism in PDD Patients
Objective: The study aims to determine whether STN-DBS brings about clinical benefits for Parkinson’s disease dementia (PDD) patients and its association with metabolic change in…Transcutaneous Afferent Patterned Stimulation: A Non-Invasive Approach to Modulate Brain Metabolism in Essential Tremor
Objective: To investigate the mechanism of transcutaneous afferent pattern stimulation (TAPS) using PET imaging to assess brain metabolic changes associated with tremor reduction in individuals…Seed-based Metabolic Networks and Time Series Variation based on Functional [18F]-FDG PET in Parkinson’s Disease
Objective: To analyse seed-based metabolic networks and time series variation in Parkinson’s disease with and without mild cognitive impairment based on functional PET (fPET) Background:…The Cholinergic System in Cervical Dystonia – An [18F]-FEOBV PET study
Objective: To investigate presynaptic cholinergic functioning in cervical dystonia (CD) by comparing [18F]-FEOBV binding in patients and controls, as well as exploring correlations with motor…Metabolic network signature of quantitative motor effects following deep brain stimulation in Parkinson’s disease
Objective: To integrate [18F]-FDG PET (fPET) and objective motor performance to unravel metabolic networks associated with deep brain stimulation (DBS) outcomes in Parkinson’s disease (PD).…Effect of Exenatide on disease progression in early Parkinson’s disease–a randomized, placebo controlled, single-center trial in Sweden
Objective: To identify biological mechanisms that mediate Exenatide's effect in the brain of patients with early Parkinson’s disease(PD). Background: Tracking PD progression remains a major challenge due to…The value of PET imaging in Parkinson’s disease with cognition impairment
Objective: The purpose of this study was to explore the diagnostic value of PET imaging, plasma biomarkers in the diagnosis of cognitive dysfunction in Parkinson's…
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