Suicidal Ideation and the Hippocampal Histaminergic System in Huntington’s Disease: A PET Study
Objective: To determine whether presence and severity of suicidal ideation (SI) are associated with hippocampal volume and histamine H3 receptor (H3R) PET uptake in people with Huntington’s disease (PwHD). Background: Suicidal ideation occurs in approximately 8–27% of PwHD, yet its causes remain unclear(1–3). The…Clinical and Multimodal Biomarker Profiles in Progressive Supranuclear Palsy: The PSPNI Cohort Study in China
Objective: To present an overview of the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI) from China. Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease…Sequential neurodegenerative trajectories across the onset of mild parkinsonian signs in isolated REM sleep behavior disorder: a longitudinal multimodal imaging study
Objective: To demonstrate the neurodegeneration status implied by mild parkinsonian signs (MPS) in patients with isolated REM sleep behavior disorder (iRBD) by analyzing longitudinal clinical…Topographic Heterogeneity of Dopaminergic Denervation and Iron Deposition in Functional Subregions of Nigrostriatal System in Parkinson’s Disease
Objective: To investigate the spatial relationship between striatal dopaminergic denervation and nigral iron accumulation in Parkinson’s disease (PD) using functional subregional parcellation. Background: Excessive nigral…The predictive value of the 18F-FDG PET-derived Parkinson’s disease Related Pattern for neurodegenerative disease progression in isolated REM Sleep Behavior Disorder
Objective: To determine whether baseline and longitudinal Parkinson’s disease–related pattern expression predicts conversion to Parkinson’s disease or dementia with Lewy bodies in idiopathic REM sleep…Does PET Imaging Modality Influence Artificial Intelligence Performance in Diagnosing Parkinson’s Disease? Diagnostic Test Accuracy Meta-analysis
Objective: To determine whether AI diagnostic performance for Parkinson’s disease differs across PET imaging platforms Background: PET-based artificial intelligence (AI) has emerged as a promising…Nigrostriatal Dopaminergic Impairment Patterns in Idiopathic Normal Pressure Hydrocephalus Identified by 18F-FP-DTBZ PET: a 5-Year Longitudinal Study
Objective: To delineate the pattern of nigrostriatal dopaminergic dysfunction in iNPH, explore inter-individual heterogeneity, and evaluate its association with clinical features and long-term outcomes. Background:…Distinct FDG-PET metabolic patterns and connectivity alterations in dopamine transporter-deficient versus -preserved MSA-C
Objective: In this study, we stratified MSA-C patients by DaT-PET binding status (preserved vs deficient) and compared their 18F-FDG PET metabolic patterns and inter-regional metabolic…Allogeneic iPSC-Derived Dopaminergic Progenitor Transplantation for Parkinson’s Disease: A Phase 1, Dose-Escalation Trial
Objective: To evaluate the safety, tolerability, and preliminary efficacy of putaminal implantation of XS411 (allogeneic iPSC-derived dopaminergic progenitors) in advanced PD (NCT07080775). Background: Parkinson’s disease (PD)…Ultra-early Diagnosis of MSA-C Using Biological Biomarkers: A Two-Case Study Employing α-Synuclein PET and Fluid α-Synuclein Seeds Amplification Assay (SAA)
Objective: To report cases in which combined α-synuclein PET and body fluid α-synuclein seeds amplification assay (SAA) enabled biological diagnosis of multiple system atrophy–cerebellar type…
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