18F-DPA714 PET reveals neuroinflammatory activity in the Substantia nigra of patients with Parkinson disease
Objective: We investigated whether 18F-DPA714 imaging could be a sensitive marker of neuroinflammation in Parkinson disease (PD). We took into account the polymorphism of TSPO…Amyloid load and cognitive decline in Parkinson’s disease: preliminary longitudinal findings
Objective: To test for any association between amyloid deposition and future cognition in Parkinson’s disease, in a sample enriched for mild cognitive impairment. Background: Progressive…[18F]THK-5351 PET Imaging in Progressive Supranuclear Palsy Concomitant with Cerebellar Ataxia in Early-stage: Clinicopathological Observations
Objective: To describe two cases of progressive supranuclear palsy (PSP) concomitant with cerebellar ataxia in early stage who underwent [18F]THK-5351 PET imaging and to investigate…Relationship between striatal dopamine depletion and various non-motor symptoms in non-demented patients with Parkinson’s disease: a pilot study
Objective: We aimed to investigate associations of striatal dopamine uptake and various non-motor symptoms in non-demented patients with Parkinson’s disease (PD). Background: Dopamine transporter (DAT)…Hemispheric Differences in Motor Circuitry of Parkinson’s disease: Metabolism and Micro-Structure
Objective: The purpose of this study was to quantitatively characterize simultaneous PET/MR brain changes focusing on the hemispheric asymmetry to trace differences between the more…Unilateral leg tremor on sitting crossed-legged position as the initial manifestation of Parkinson’s disease
Objective: Our aim is to report an unusual case of initial manifestation of Parkinson's disease, which showed unilateral leg tremor on sitting crossed-legged position on…APOmorphine infusion and aMYLoid deposition in Parkinson’s disease (APOMYL): preliminary clinical and amyloid imaging data
Objective: To explore the potential effects of chronic Apomorphine infusion treatment on reducing brain Amyloid-b (Aβ) deposition in Parkinson’s disease (PD). Background: A majority of…Metabolic network abnormalities in drug-naive Parkinson’s disease
Objective: The objective of this study is to identify and validate the metabolic PD-related pattern (PDRP) in de novo PD patients and to compare it…Identification and Characterization of Selective and High Affinity Small Molecules as Positron Emission Tomography (PET) Imaging Tracers for Pathological Alpha-Synuclein
Objective: The aim is to develop small molecular weight compounds which bind selectively and with high affinity to alpha-synuclein (a-syn) aggregates as diagnostic PET imaging…Measuring progression of nigrostriatal degeneration in Parkinson’s disease using 18F-AV-133 vesicular monoamine transporter type-2 (VMAT2) PET
Objective: To evaluate the progression of nigrostriatal degeneration in participants with Parkinson’s disease (PD) using 18F-AV-133 vesicular monoamine transporter type-2 (VMAT2) PET. Background: Vesicular monoamine…
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