DNAJC13 in Parkinson’s disease; characterization of the p.N855S knock-in mouse model
Objective: To study the effects of DNAJC13 p.Asn855Ser mutant gene dysfunction in a physiological context, and to help define molecular mechanisms for disease, using a…Clinical and DAT Imaging Characteristics of Participants with Scans without Evidence of Dopaminergic Deficit (SWEDDs): PPMI Cohort 2 year follow-up
Objective: To examine the clinical and biological characteristics of participants with scans without evidence of dopaminergic deficit (SWEDD) during a two-year follow-up. Background: Study participants…Comparison of PDE10A and DAT expression as markers of disease burden in early Parkinson’s disease
Objective: We aimed to compare loss of PDE10A and DAT expression in patients with Parkinson’s disease. Background: Recent work has shown loss of PDE10A expression…Age-related failure in compensatory mechanisms and its relation to the Parkinson phenotype: evidence from a SPECT study in early and late-onset PD
Objective: To investigate if a less prominent dopaminergic dysfunction on 123I-ioflupane SPECT imaging (DaTSCAN) despite a more severe motor phenotype in Late Onset Parkinson’s Disease…Dopaminergic imaging in patients with basal ganglia calcification presenting with parkinsonism
Objective: To evaluate the integrity of the nigro-striatal system with single photon emission computed tomography imaging with dopamine transporter (DaTscan) in patients with basal ganglia…Neuroinflammation Predicts Dompaminergic Deficit in Early Parkinson Disease: DAT SPECT Imaging Study
Objective: We aimed to investigate whether striatal Dopamine transporter (DaT) uptake could be predicted by Neutrophil to lymphocyte ratio (NLR) or measures of disease severity…Biofabricated tissue constructs to recapitulate the anatomy and functionality of the nigrostriatal pathway in Parkinson’s disease
Objective: 1) Biofabricate constructs that mimic the cytoarchitecture and function of the nigrostriatal pathway, and 2) Microinject constructs to assess restoration of dopaminergic input to…Does dopaminergic denervation of specific anatomical regions of the basal ganglia correlate with clinical features of Parkinsonism: A quantitative DaTscan study
Objective: To correlate different clinical features of parkinsonism with regional variations of presynaptic dopaminergic dysfunction of the basal ganglia using quantitative DaTscans. Background: DaT-SPECT imaging…Putaminal dopamine depletion in de novo Parkinson’s disease predicts future development of wearing-off
Objective: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson’s disease.…Early caudate involvement in Parkinson’s disease may predict future cognitive decline
Objective: 1. To investigate prevalence of caudate dopaminergic dysfunction as measured by 123I-FP-CIT in a large cohort of early stage (< 2 years disease duration)…