Comparison of PDE10A and DAT expression as markers of disease burden in early Parkinson’s disease
Objective: We aimed to compare loss of PDE10A and DAT expression in patients with Parkinson’s disease. Background: Recent work has shown loss of PDE10A expression…Biofabricated tissue constructs to recapitulate the anatomy and functionality of the nigrostriatal pathway in Parkinson’s disease
Objective: 1) Biofabricate constructs that mimic the cytoarchitecture and function of the nigrostriatal pathway, and 2) Microinject constructs to assess restoration of dopaminergic input to…Does dopaminergic denervation of specific anatomical regions of the basal ganglia correlate with clinical features of Parkinsonism: A quantitative DaTscan study
Objective: To correlate different clinical features of parkinsonism with regional variations of presynaptic dopaminergic dysfunction of the basal ganglia using quantitative DaTscans. Background: DaT-SPECT imaging…Putaminal dopamine depletion in de novo Parkinson’s disease predicts future development of wearing-off
Objective: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson’s disease.…Neuroinflammation Predicts Dompaminergic Deficit in Early Parkinson Disease: DAT SPECT Imaging Study
Objective: We aimed to investigate whether striatal Dopamine transporter (DaT) uptake could be predicted by Neutrophil to lymphocyte ratio (NLR) or measures of disease severity…Relationship between cognitive dysfunction and striatal uptake of 123I-FP-CIT in patients with Parkinson’s disease
Objective: The objective of this study is to investigate a relationship between cognitive dysfunction and striatal uptake of 123I-FP-CIT SPECT (dopamine transporter (DAT) SPECT) in…Associations of DAT SPECT and TCS with prodromal features of Parkinson’s disease: results in PREDICT-PD participants
Objective: To examine whether changes on dopamine reuptake transporter (DAT) SPECT and transcranial sonography (TCS) correlated with Parkinson’s disease (PD) risk scores and other prodromal…SPECT imaging of striatal DAT availability in Parkinson’s: changes over time and relevance to dyskinesias
Objective: This study was designed to explore in Parkinson’s disease (PD) the role of dopamine transporter (DAT)-specific single photon emission computed tomography (SPECT) imaging as a…Early caudate involvement in Parkinson’s disease may predict future cognitive decline
Objective: 1. To investigate prevalence of caudate dopaminergic dysfunction as measured by 123I-FP-CIT in a large cohort of early stage (< 2 years disease duration)…Global Regulatory Agencies Support the Use of Dopamine Transporter Neuroimaging for Subject Selection in Clinical Trials Targeting Early Stage Parkinson’s Disease – on behalf of Critical Path for Parkinson’s (CPP) Consortium
Objective: A key goal of the Critical Path for Parkinson’s Consortium (CPP) is to qualify, with regulatory agencies, drug development tools for use in PD…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.