ARISE study: Study Design and Baseline Characteristics for a Phase 2 Trial of the Anti-Tau Antibody ABBV-8E12 in Progressive Supranuclear Palsy
Objective: This double-blind, placebo-controlled phase 2 study (M15-562 ARISE study, NCT02985879) assesses the safety and efficacy of ABBV-8E12 treatment in patients with progressive supranuclear palsy…Referral and diagnostic time intervals from symptom onset to death in progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Parkinson’s disease (PD)
Objective: To compare referral and diagnostic time intervals from index symptom to death in PSP/CBD and age-sex matched PD. Background: Misdiagnosis and delayed diagnosis are…PASSPORT, An Ongoing Phase 2 Study in Patients with PSP– Baseline Characteristics
Objective: To describe baseline characteristics of the participants with progressive supranuclear palsy (PSP) enrolled in the ongoing PASSPORT (NCT03068468) phase 2 study. Background: PSP is…Striatal FP-CIT SPECT findings for progressive supranuclear palsy subtypes
Objective: In our previous study FP-CIT SPECT (FP-CIT) in progressive supranuclear palsy-Parkinsonism (PSP-P) revealed higher anterior striatal accumulation, and PSP- Richardson’s syndrome (PSP-RS) revealed lower…Expanding the NINDS Parkinson’s Disease Biomarkers Program – Utilizing a Major Biomarker Resource to Address Atypical Parkinsonisms and Related Conditions
Objective: Expansion of a carefully curated resource for clinical and biosample data to address a critical need for biomarker discovery in Atypical Parkinsonisms and related…Gait and Cognition in Progressive Supranuclear Palsy: A Significant Association
Objective: In this study we explored the association between gait parameters and cognitive function of PSP. Background: Gait and cognition are interrelated in patients with…Anatomical predictors of survival in PSP: thalamic collapse towards the end of life
Objective: To correlate anatomical changes with time to death in PSP. Background: Many advances have been made in progressive supranuclear palsy (PSP) since it was first described…Gait characteristics in Atypical Parkinsonism
Objective: We investigated gait characteristics of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), with the aim to elucidate relatively specific disease differences in…Clinicopathological analysis of corticobasal syndrome: a retrospective study
Objective: Predicting underlying pathology in CBS. Background: Corticobasal syndrome (CBS) is pathologically heterogeneous. CBS is one of the clinical phenotypes of corticobasal degeneration (CBD) but may…Freezing of gait is an early clinical feature of progressive supranuclear palsy
Objective: We attempted to identify any sign or symptom to diagnose progressive supranuclear palsy (PSP) earlier. Background: Early clinical diagnosis of progressive supranuclear palsy PSP…
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