A novel phenotype of amyloid precursor protein (APP) mutation presenting with dementia, and symptoms of both progressive supranulcear palsy (PSP) and multisystem atrophy (MSA)
Objective: To describe the novel phenotype of a patient with an amyloid precursur protein (APP) mutation presenting with dementia and symptoms of both progressive supranulcear…Dorsal simultanagnosia as a cortical sign in the tauopathy spectrum
Objective: Clinical characterization of a tauopathy spectrum patient. Background: In recent years phenotypic overlap has been demonstrated between patients with progressive supranuclear palsy (PSP) pathology…Multimodal voxel-based analysis of the infratentorial brain region in Richardson’s syndrome, progressive supranuclear palsy-parkinsonism, Parkinson variant of multiple system atrophy and Parkinson’s disease
Objective: Voxel-based analysis was applied to MRI parameters of iron content (transverse relaxation rate, R2*), microstructural integrity including mean diffusivity (MD) and fractional anisotropy (FA)…Effectiveness of Levodopa responsiveness of Blink reflex recovery: An objective method to differentiate Parkinsonian syndromes
Objective: We attempted to find an objective tool by assessing the variability of levodopa induced change in the blink reflex recovery to differentiate Parkinsonian syndromes.…Imaging correlates of hypodipsia in progressive supranuclear palsy
Objective: Aims of the present study were• to confirm hypodipsia as a characteristic feature of PSP and• to offer hypothesis on the pathological substrate for…Oxysterol and chitotriosidase as biomarkers for atypical Parkinsonian symptoms?
Objective: The aim of the study is to establish chitotriosidase and oxysterols as a biomarker for atypical Parkinsonian syndromes in order to make a distinction…Prevalence and incidence of PSP and CBS: A new prospective study in the UK
Objective: To estimate the prevalence and incidence of progressive supranuclear palsy (PSP, 'Richardson's syndrome') and corticobasal syndromes (CBS); in the context of all clinical phenotypes…Social cognition assessment in progressive supranuclear palsy: The cognitive interface with frontotemporal dementia
Objective: To explore the cognitive profile of PSP patients in tests of social cognition and to compare their performance to patients with behavioural variant frontotemporal…A longitudinal observational study of a cohort of patients with PSP/CBD: The JALPAC project
Objective: To identify PSP/CBD progression biomarkers both to improve understanding of disease etiology and course, and to provide crucial tools to enhance the likelihood of…Subjective report does not predict objective swallow impairment in atypical Parkinsonian syndromes
Objective: Swallow and speech disturbances are common in patients with atypical parkinsonism. The emergence of swallowing problems, or dysphagia, is associated with increased morbidity and…
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