Item – Level Drivers of Certification Failure in the MDS-UPDRS Motor Examination: A Five-Year Global Analysis
Objective: To identify individual Part III items that disproportionately contribute to first-attempt certification failure and to evaluate the stability of these patterns over five years.…Clinical instability and fluctuations as an early marker of accelerated progression
Objective: To determine whether early clinical instability, quantified through combined motor and non-motor fluctuations, predicts a more severe longitudinal disease course in Parkinson’s disease. Background:…Exploring a Milestone-Based Approach as an Outcome Measure for Disease-Modifying Parkinson Disease Trials
Objective: To replicate a composite milestone(CM) approach in a range of Parkinson Disease(PD) studies(observational, clinical trials) over a long time period(up to 12 years). To…Associations Between FDG-PET Regional Metabolism and Clinical Severity in Progressive Supranuclear Palsy
Objective: To characterize the clinical profile, disease progression, and their associations with neuroimaging biomarkers in patients with Progressive Supranuclear Palsy (PSP). Background: PSP encompasses a…Patient-Defined Disease Progression in Parkinson Disease: Towards Patient-Relevant Outcome Measures
Objective: To carry out a survey on a representative sample of people with Parkinson’s (PwP) about their lived experience of a comprehensive list of Parkinson…Beyond Motor Outcomes: Health Literacy, Medication Adherence, and Quality of Life in Parkinson’s Disease Patients Undergoing the Levodopa Challenge Test
Objective: To characterize health literacy (HL), medication adherence, satisfaction with medication information, and quality of life (QoL) in Parkinson’s disease (PD) patients undergoing the levodopa…Prospective Evaluation of a Video-Based Motor Assessment Workflow: Feasibility, Usability, and Data Quality
Objective: To prospectively evaluate the feasibility, usability, and data quality of a video-based motor assessment platform (PRIMS) in a clinic setting, and to examine agreement…Interplay of sex and GBA1 and LRRK2 genotype in Parkinson disease progression
Objective: To characterize disease heterogeneity and how sex impacts motor and cognitive progression class membership across genetic subgroups of GBA1, LRRK2, and idiopathic Parkinson disease (PD). Background: Autosomal…Non-motor symptoms in Huntington’s disease: Results from the Validation of the Non-motor Symptoms Scale (MDS-NMS)
Objective: To present validation results of the Movement Disorder Society Non-Motor Symptoms Scale (MDS-NMS), originally developed for Parkinson’s disease, for use in people with Huntington’s…Phenomenological Gaps in Rating Scales for Blepharospasm Motor Severity
Objective: To evaluate domain coverage of rating scales used to quantify motor severity of blepharospasm (BSP). Background: BSP rating scales have been evaluated for their…
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