Clinical Significance of Imaging Markers for Cerebellar Ataxia and Parkinsonism in Multiple System Atrophy
Objective: To clarify the interactions among clinical features and imaging markers, and to identify factors contributing to disease severity in MSA. Background: Multiple system atrophy…Nigrostriatal Dopaminergic Patterns in Dementia with Lewy Bodies and Parkinson’s Disease Subtypes: A DAT-SPECT Study within the SOC Framework
Objective: To determine whether the pattern of nigrostriatal dopaminergic degeneration in DLB mirrors that of “body-first” PD using DAT-SPECT imaging. Background: Dementia with Lewy bodies…Disparate Subregional Striatal DAT-SPECT Associations with CSF-Synucleinopathy Status and Clinical Severity Across Parkinson’s Disease Continuum
Objective: To determine the association between subregional DAT binding ratios (SBRs) for disease risk, PD progression, and whether these associations differ based on SAA status.…Biomarker and Clinical Correlates of Restless Legs Syndrome (RLS) in Parkinson’s Disease: A Paradoxical Hyperdopaminergic State
Objective: To examine the clinical and biomarker correlates of Restless legs syndrome (RLS) in Parkinson’s disease (PD). Background: RLS is more common in PD than…Effects of Repetitive Deep TMS on Motor Function and Cerebral Perfusion in Parkinson’s Disease
Objective: This study aimed to investigate the effects of deep repetitive transcranial magnetic stimulation (dTMS) using an H-coil on cerebral perfusion and motor function in…Early Caudate Dopaminergic Loss as an Imaging Biomarker of Cognitive Impairment in Parkinson’s Disease: A Longitudinal Analysis
Objective: The primary objective was to determine whether early pre-synaptic caudate denervation, measured using 123 I ioflupane SPECT quantitative metrics, provides independent and incremental prognostic value…fMRI Activity during Working Memory Manipulation is Associated with Caudate Integrity in Early Parkinson’s Disease
Objective: This study aimed to determine whether reduced dopaminergic integrity and increased iron deposition in the caudate are associated with altered BOLD activation during high…Semiquantitative [¹²³I]FP-CIT SPECT metrics combined with machine learning improve clinical differentiation of parkinson’s disease and atypical parkinsonian syndrome
Objective: To evaluate the capacity of semiquantitative striatal [¹²³I]FP-CIT SPECT-derived metrics to improve the clinical differentiation of degenerative parkinsonism through an integrated machine learning model.…Dynamic and Multimodal Prediction of Phenoconversion to Cerebellar Multiple Sytem Atrophy among Sporadic Late-Onset Cerebellar Ataxia
Objective: To dynamically predict phenoconversion from a sporadic late-onset cerebellar ataxia (SLOCA) phenotype to MSA-C. Background: Cerebellar multiple system atrophy (MSA-C) is diagnosed according to…A Dopamine Clock for Biological Staging of Parkinson’s Disease
Objective: To develop a dopamine transporter (DAT) SPECT imaging staging framework for Parkinson’s disease (PD) using a latent disease-time model that quantifies progression as a…
- 1
- 2
- 3
- …
- 16
- Next Page »