Brain perfusion patterns associated with motor symptoms in multiple system atrophy
Objective: There is a need for objective methods to assess disease progression in multiple system atrophy (MSA). This study aimed to identify brain perfusion patterns…Cerebrospinal fluid DOPA decarboxylase levels as a marker of disease severity in Parkinson’s Disease
Objective: To assess the correlation of CSF DDC levels to DaT-SPECT SBR in PD and iRBD. Background: Raised cerebrospinal fluid (CSF) proteomic biomarker, DOPA decarboxylase…Results From a Dose-Blinded, Phase II Extension Study Evaluating Long-Term Efficacy, Safety and Tolerability of Minzasolmin in Participants With Parkinson’s Disease
Objective: ORCHESTRA XT (PD0055; NCT05543252) was a Phase II, dose-blinded extension of the ORCHESTRA Phase II, proof-of-concept study (NCT04658186). ORCHESTRA XT assessed the pharmacodynamic effects of…Identifying subjects at high risk for prodromal Parkinson’s Disease using dopamine transporter imaging deficit in a step-wise recruitment strategy: Data of Healthy Brain Ageing (HeBA)
Objective: To optimize screening for subjects with dopamine transporter (DaT) imaging deficit being at high risk for prodromal Parkinson's disease (PD). Background: Efficient screening methods…A Prospective, Observational Study to Identify Biomarkers in Parkinsonian Syndromes (proATYP).
Objective: This is a prospective observational study to identify biomarkers in parkinsonian syndromes. Background: Parkinson’s disease (PD) and atypical parkinsonian syndromes namely progressive supranuclear palsy…A multi-center, randomized, controlled study of the add-on effect of selegiline or zonisamide to L-dopa/DCI therapy in Parkinson’s disease (DATSZ-PD study)
Objective: To investigate the efficacy and safety for neuroprotection and disease modifying effect in selegiline(SL) or zonisamide(ZN) by using UPDRS, PDQ-39 and DAT -SPECT in…Dopamine Transporter Imaging as a Predictor of Functional Outcomes in Parkinson’s Disease
Objective: To evaluate the prognostic value of dopamine transporter (DAT) imaging in predicting future disability, as well as motor and non-motor burden, in Parkinson’s disease…Semi-quantitative Evaluation of Midbrain Accumulation in 123I-FP-CIT SPECT in Parkinson’s disease and Parkinsonian Syndromes
Objective: To establish a method for evaluating midbrain accumulation of 123I-FP-CIT SPECT and assess its ability to differentiate between Parkinson’s disease (PD) and Parkinsonian syndromes…Identifying Cut-off Values, Effects of AD Co-pathology, Sex Differences, and Temporal Changes of 123I-FP-CIT SPECT in Autopsy-proven LBD
Objective: We analyzed autopsy-proven Lewy body disease (LBD) and/or Alzheimer’s disease (AD) dementia patients with 123I-FP-CIT SPECT to investigate previously unclarified detailed aspects of 123I-FP-CIT…Preoperative Occipital Hypoperfusion Predicts Cognitive Decline after Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
Objective: This study aimed to identify the preoperative cerebral blood flow (CBF) regions associated with frontal lobe dysfunction after subthalamic nucleus deep brain stimulation (STN…
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