Continuous circadian intracerebroventricular administration of anaerobically preserved dopamine greatly reduces severe L-dopa-related complications in Parkinson’s disease
Objective: We aim to demonstrate the safety and efficacy of continuous circadian intracerebroventricular (i.c.v.) administration of anaerobic-dopamine (A-dopamine) to reduce the L-dopa-related complications (LDRC) in…Intraoperative quantification of MDS-UPDRS tremor measurements using 3D accelerometry
Objective: This study focuses on translating parkinsonian tremor tests to an objective method to rate tremor severity using 3D accelerometry, that can be used during…Impact of rs6265 in the Host and Donor on Dopamine Neuron Graft Function.
Objective: Extend investigations into the effect of the rs6265 single nucleotide polymorphism (SNP) on dopamine (DA) neuron graft efficacy using a parkinsonian rat model. Background:…Magnetic Resonance Image-guided high-intensity focused ultrasound (MRIgFUS) subthalamotomy in Spanish Parkinson’s disease (PD) patients.
Objective: To describe our preliminary results of MRIgFUS subthalamotomy in two PD patients. Background: MRIgFUS thalamotomy has become the preferred surgical approach for refractory essential tremor…Knowledge and Attitudes among young Neurologists towards Surgery in Movement Disorders
Objective: To assess the knowledge and attitudes of young neurologists towards the surgical interventions in movement disorders. Background: Surgical management of patients with movement disorders…Evolving inclusion criteria in early manifest Huntington’s disease (HD) to address striatal atrophy: Lessons from HD-GeneTRX-1, the first gene therapy trial
Objective: To describe the early screening experience and evidence-based adaptations to the inclusion criteria for HD-GeneTRX-1 (NCT04120493). Background: AMT-130 is an AAV5-based gene therapy intended…Role of the Stereotactic Dentatotomy for the management of Movement Disorders
Objective: Evaluate the antecedents about the clinical outcomes of stereotactic dentatotomy in the management of diverse motor disorders. Background: The dentatotomy is a surgical technique…A retrospective analysis of Movement Disorder Patient Referrals for Functional Neurosurgery in the Neurosciences Department of Mater Dei Hospital
Objective: Malta has a population of just under 450 000. The estimated number of patients likely to benefit from functional neurosurgery including Deep Brain Stimulation…Anodic stimulation reduces corticospinal tract engagement in STN-DBS for Parkinson’s disease: a case report.
Objective: To seek how novel programming options modify the therapeutic window in a case of off-targeting DBS. Background: In Parkinson’s disease deep brain stimulation (DBS)…Deep Brain Stimulation of Anterior Globus Pallidus internus Reduces Impulsivity in Parkinson’s Disease
Objective: To evaluate whether selective deep brain stimulation (DBS) stimulation of anterior region of globus pallidus internus (GPi) affects impulsivity in Parkinson’s Disease patients Background:…
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