Age-associated changes in the striatal proteins in aging Asian-Indians
Objective: To examine the age-related changes in tyrosine hydroxylase (TH), vesicular monoamine transporter2 (VMAT2), post-synaptic density protein-95 (PSD-95) and dopamine receptors (D1R, D2R) expression in the…AAV5-miHTT gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington’s disease minipigs up to 5 years
Objective: Our objective is to assess long-term safety of and durability of an adeno-associated viral vector serotype 5 encoding an engineered miRNA (AAV5-miHTT) targeting human…Dopamine depletion of striatal subregions and motor dysfunction in prodromal and clinical Parkinson’s disease
Objective: This aim of this study was to investigate how dopamine depletion of different striatal subregions contributes to motor symptoms in patients with prodromal and…Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…Distinct striatal connectivity patterns in patients with Parkinson’s disease with and without urinary symptoms
Objective: To investigate the potential effect of urinary symptoms on the regional striatal functional connectivity (FC) in a cohort of drug-naïve PD patients applying a…Striatal neurodegeneration in female carriers of the TAF1 Mutation Causing X-linked Dystonia-Parkinsonism
Objective: To determine whether structural brain changes are present in female carriers (MC) of the TAF1 pathogenic change causing X-linked dystonia-parkinsonism (XDP). Background: XDP is an X-linked…Concordant RNA patterns in Parkinson’s disease brain and peripheral blood.
Objective: To investigate the molecular correlates of clinical heterogeneity in Parkinson’s disease (PD) in the striatum and peripheral blood. Background: The molecular basis for clinical…The effect of short-term treadmill exercise in the alpha-synuclein preformed fibril rat model of Parkinson’s disease
Objective: To determine how treadmill exercise impacts behavior and Parkinson-related pathology in the alpha-synuclein (a-syn) preformed fibril (PFF) model. Background: Exercise is often recommended by…Prediction of early-stage Parkinson’s disease using connectivity and morphometry of the striatum
Objective: To parcellate the striatum into sub-regions and extract connectivity and surface morphometry features that can distinguish early patients with PD using machine learning. Background:…Chorea Hyperglycemic Basal Ganglia syndrome(CHBG) with Diabetic Lumbosacral Radiculoplexus Neuropathy – A rare case presentation
Objective: To demonstrate that metabolic derangement can lead to choreiform movement disorder. Background: Hemichorea are involuntary, non-patterned movement disorders caused by lesions of the contralateral…
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