Translation of a subject-specific stereotaxic platform to a large animal deep brain stimulation research models
Objective: To evaluate the feasibility and accuracy of applying the commercially-available, FHC STarFix platform system for direct targeting of deep brain stimulation electrodes in a…Online determination of the STN “sweet spot” based on beta-power measured with directional macro-contacts of the final DBS lead
Objective: Microelectrode recordings are the standard procedure for intraoperative, electrophysiological mapping of the STN[1]. We investigated a novel methodology to detect the STN sweet spot…Assessment of Neuropsychological Outcomes Using a New Multiple Source, Constant- Current Rechargeable Deep Brain Stimulation System for the Treatment of Parkinson’s Disease – INTREPID Study
Objective: To evaluate neuropsychological outcomes in subjects participating in the INTREPID randomized controlled trial (RCT). Background: Neuropsychological evaluation in the context of Deep Brain Stimulation…Development of an unsupervised analysis pipeline for human microelectrode recordings
Objective: Our aim is to develop computational tools that can assist clinical decision in Deep Brain Stimulation (DBS) for Parkinson's disease (PD) using intraoperative microelectrode…Effects of Directional Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s disease
Objective: To assess if a horizontal current steering in the subthalamic nucleus (STN) by directional deep brain stimulation (dDBS) offers clinical advantages compared to conventional…Quantitative assessment of the effectiveness of adaptive Deep Brain Stimulation in Parkinson’s disease
Objective: To determine the effectiveness of Adaptive Deep Brain Stimulation (aDBS) in PD patients compared to cDBS and non-medicated PD patients (OFF). Background: aDBS based…STN-DBS causing persistent dyskinetic movements in OFF-State
Objective: Transient choreatic movements are known as side effects of DBS of the dorsolateral STN in Parkinson disease (PD). Persistent “brittle” dyskinesia have been reported…Contribution of ATP-sensitive potassium channels in the subthalamic nucleus neurons towards Parkinson’s disease
Objective: This study describe a quantitative investigation to explore the modulating effects of the ATP-dependent Potassium channel (KATP) ion channel conductance on spike patterns in…Phenomenology and management of subthalamic stimulation-induced dyskinesia in a video case series of patients with isolated dystonia
Objective: To document with videotaped observations, 3 patients with isolated dystonia who experienced stimulation-induced dyskinesia (SID) following subthalamic nucleus (STN) deep brain stimulation (DBS). Background:…The Effect of Short Pulse Width Settings on Speech in Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s disease
Objective: To compare perceptual characteristics and intelligibility of speech in Parkinson's Disease (PD) patients with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) in the acute setting…
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