INTREPID: A Prospective, Double Blinded, Multicenter Randomized Controlled Trial Evaluating Deep Brain Stimulation with a New Multiple Source, Constant Current Rechargeable System in Parkinson’s disease
Objective: INTREPID is designed to assess the improvement in motor function and quality of life in patients with Parkinson’s disease (PD) following Deep Brain Stimulation…Comparison of low-frequency stimulation versus high-frequency stimulation of the subthalamic nucleus on cerebral hemodynamics in Parkinson’s disease: A transcranial Doppler Study
Objective: Parkinson’s disease (PD) is the second most frequent progressive neuro-degenerative disease and the Deep Brain Stimulation (DBS) is a useful surgical treatment to treat…Patterns of rhythmic single unit activity of the subthalamic nucleus in patients with Parkinson’s disease
Objective: The study of rhythmic neuronal activity is of great interest as they may have implications for pathophysiological mechanisms of PD. The aim of this…Intraoperative local field potential recordings from deep brain stimulation electrodes help predict efficacy of subthalamic nucleus stimulation in patients with Parkinson’s disease
Objective: Subthalamic nucleus (STN) deep brain stimulation(DBS) is an effective treatment for advanced Parkinson's disease (PD). Two electrophysiological techniques aid identification of the optimal target.…Surgery-, hardware – and chronic stimulation-related adverse events following subthalamic nucleus deep brain stimulation for Parkinson’s disease
Objective: To evaluate the adverse events (AEs) following subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson’s disease (PD) during 6 years period. Background: The…Subthalamic nucleus stimulation normalises effort-based decision-making in Parkinson’s disease
Objective: To compare the influence of levodopa and subthalamic nucleus stimulation (STN-DBS) on effort-based decision-making in Parkinson’s disease (PD). Background: Idiopathic PD is a neurodegenerative…Toward optimized nonlinear deformation algorithms for subcortical DBS target regions in MRI
Objective: 1. To evaluate and optimize subcortical accuracy of commonly used nonlinear deformation algorithms. 2. To optimize accuracy of automated atlas-based segmentation of the two…Evaluation of apathy before and after subthalamic nucleus deep brain stimulation therapy in advanced Parkinson’s disease patients
Objective: Deep brain stimulation (DBS) has been approved to relieve the motor symptoms of Parkinson's disease (PD) patients when the optimal pharmachologic treatment is unsatisfactory.…Levodopa and subthalamic stimulation do not have the same effect on subjective cost for distal and axial efforts in Parkinson’s disease
Objective: To compare the effects of levodopa and subthalamic nucleus stimulation (STN-DBS) on decision-making tasks for distal (hand) and axial (speech) efforts in Parkinson’s disease…An Objective Tool to Guide Target Selection for DBS in PD (GPi vs STN)
Objective: To create a simple tool to aid in selection of the proper target for Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD). Background: Two…
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