Optimization of Synucleinopathy and Nigrostriatal Degeneration Induced by Injection of Alpha-Synuclein Preformed Fibrils into Rat Striatum
Objective: Optimization of the surgical parameters (intrastriatal placement and concentration of alpha-synuclein preformed fibrils; α-syn PFFs) to increase the magnitude of nigrostriatal α-syn pathology and…Genetic knock-down of HDAC4 attenuates rotenone-induced abnormal expression of α-synuclein by affecting autophagic flux in SH-SY5Y Cells
Objective: To assess whether histone deacetylase 4 (HDAC4) is related to the abnormal expression of α-synuclein (α-syn) via the autophagy pathway. Background: The overexpression and…Targeting alpha-Synuclein Aggregation for the Treatment of Parkinson’s Disease
Objective: To develop small molecular weight compounds (SMEs) as disease-modifying agents, which are designed to arrest or even reverse the aggregation process of alpha-synuclein (aSyn)…Results From a Phase 1b Multiple Ascending-Dose Study of PRX002, an Anti–Alpha-Synuclein Monoclonal Antibody, in Patients with Parkinson’s Disease
Objective: To evaluate PRX002 in patients with PD in a double-blind, placebo-controlled, phase 1b multiple ascending-dose study. Background: PRX002 (RG7935) is an investigational monoclonal antibody…Alpha synuclein and crystallin expression in human lens in Parkinson’s disease
Objective: To determine the Protein Profile of cataract lenses in Parkinson's disease (PD). Background: Protein accumulation, mainly αB-crystallin, in the lens causes cataract. PD is…Characteristics of the interaction between different toxic aggregated species of alpha-synuclein and cell membrane
Objective: To determine (1) the interaction rate of each toxic aggregated species of alpha-synuclein (α-Syn) with cell membrane compare to the monomeric form, (2) the…A novel single molecule imaging approach to detect individual protein oligomers in CSF from patients with Parkinson’s disease (PD)
Objective: (1) To develop an ultra-sensitive method to visualize single amyloid oligomers and (2) to compare the oligomer load in CSF from patients with PD…Targeting TLR4 for disease modification in multiple system atrophy: Experimental evidence
Objective: To assess the efficacy of toll-like receptor 4(TLR4) agonists to ameliorate the functional and neuropathological phenotype of a transgenic mouse model of multiple system…Detailed proteomic analysis of early PD brain highlights altered expression of mitochondrial proteins as an important event in sporadic PD
Objective: To uncover early pathogenic events occurring prior to neuronal loss and Lewy body formation in human PD brain. Background: In PD, pathological changes spread…Progression of microglial activation and neuroinflammatory responses in a transgenic mouse model of multiple system atrophy
Objective: Our aim was to characterize the progression of microglial activation during disease progression in a transgenic mouse model of multiple system atrophy (MSA). Background:…
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