What Moves in the Night: Differences in Dream Quality Between REM Sleep Behavior Disorder and Trauma Associated Sleep Disorder
Objective: Explore differences in dream quality between REM Sleep Behavior Disorder (RBD) and Trauma Associated Sleep Disorder (TASD). Background: Idiopathic RBD is known to progress…LED Light as an Inductor of Optogenetic Activation of Astrocytes in Multiple System Atrophy
Objective: The pathogenesis of Multiple System Atrophy (MSA) involves the spread of misfolded α-synuclein from nerve cells to glia and dysfunction of mitochondria and proteasomes,…Characterization of autonomic dysfunction in prodromal and early stages of Parkinson’s Disease
Objective: To evaluate cardiovascular autonomic dysfunction across prodromal stages of synucleinopathies (Pure Autonomic Failure-PAF); isolated REM Sleep Behavior Disorder-iRBD) and early stages of Parkinson’s disease…Exploring Cardiac Autonomic Dysfunction in Synucleinopathies with Parkinsonism Across Awake-Sleep Stages
Objective: To explore the differences in heart rate variability (HRV) across awake-sleep stages between patients with synucleinopathies and elderly controls without parkinsonism Background: A complex…Preliminary Results From an Italian Multicentric Study on Inherited Synaptopathies Characterized by Movement Disorders and Epilepsy
Objective: To present the preliminary results of an Italian multicentric study on inherited synaptopathies Background: Inherited synaptopathies are rare genetic disorders characterized by complex and…Proactive Brain Health Alliance Serving Those at Risk for Neurodegenerative Disease
Objective: Research advancements enable earlier identification of neurodegenerative disease risk via prodromal symptoms and genetic and biomarker testing. Those in the “space between” risk and…Parkinson’s Progression Markers Initiative (PPMI): A Biomarker Engine for Therapeutic Development for PD and Related Synucleinopathies
Objective: PPMI is a longitudinal, observational study investigating clinical, imaging, genetic and biofluid biomarkers to accelerate therapeutic development for Parkinson’s disease (PD) and related synucleinopathies…Contribution of β-band functional connectivity to the α-synuclein propagation in early-stage Parkinson’s Disease: insights from the analysis of brain network properties
Objective: To investigate the relationship between CSF α-synuclein levels and EEG-based network properties, aiming to clarify their role in PD pathophysiology. Background: Parkinson’s disease (PD)…Assessment of the impact of the diabetic features hyperglycemia and insulin resistance on fibril induced synucleinopathy
Objective: Investigate the effects of diabetic features on the induction and severity of synucleinopathies such as Parkinson’s disease (PD). Background: Type 2 diabetes (T2D) is…Disease Modifying Potential of a Novel ROCK Inhibitor in Rodent Models of Synucleinopathy
Objective: Evaluate the impact of a novel Rho-associated kinase (ROCK) inhibitor on alpha-synuclein (a-syn) pathology, neuroinflammation, and dopamine neurodegeneration in the AAV-a-syn overexpression and a-syn…
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