Impact of Skin Biopsy Detection of Phosphorylated Alpha-Synuclein and its Distribution Patterns on the Diagnosis of Synucleinopathies
Objective: To assess how skin biopsy detection of phosphorylated alpha-synuclein (P-SYN) and its distribution pattern impact the diagnosis of synucleinopathies, such as Parkinson’s disease (PD),…Pathology Meets Clinical Practice: Unveiling the Pathological Evidence of Clinical Signs in Multiple System Atrophy
Objective: This study aimed to evaluate the pathological evidence of the core and supportive clinical features of multiple system atrophy (MSA) based on The Movement…Biological Characteristics of Individuals with RBD: A Multicenter Prospective Longitudinal Cohort
Objective: Examine baseline clinical and biological characteristics of participants with polysomnography-confirmed REM Sleep Behavior Disorder (RBD). Background: RBD is an early manifestation of underlying synucleinopathy…Plasma Neurofilament Light Chain and Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder: A Biomarker for α-Synucleinopathy Progression
Objective: This study aims to assess plasma NfL levels in iRBD and their utility in detecting early neurodegenerative changes. Background: Rapid-Eye-Movement (REM) sleep behavior disorder…What Moves in the Night: Differences in Dream Quality Between REM Sleep Behavior Disorder and Trauma Associated Sleep Disorder
Objective: Explore differences in dream quality between REM Sleep Behavior Disorder (RBD) and Trauma Associated Sleep Disorder (TASD). Background: Idiopathic RBD is known to progress…LED Light as an Inductor of Optogenetic Activation of Astrocytes in Multiple System Atrophy
Objective: The pathogenesis of Multiple System Atrophy (MSA) involves the spread of misfolded α-synuclein from nerve cells to glia and dysfunction of mitochondria and proteasomes,…Characterization of autonomic dysfunction in prodromal and early stages of Parkinson’s Disease
Objective: To evaluate cardiovascular autonomic dysfunction across prodromal stages of synucleinopathies (Pure Autonomic Failure-PAF); isolated REM Sleep Behavior Disorder-iRBD) and early stages of Parkinson’s disease…Exploring Cardiac Autonomic Dysfunction in Synucleinopathies with Parkinsonism Across Awake-Sleep Stages
Objective: To explore the differences in heart rate variability (HRV) across awake-sleep stages between patients with synucleinopathies and elderly controls without parkinsonism Background: A complex…Preliminary Results From an Italian Multicentric Study on Inherited Synaptopathies Characterized by Movement Disorders and Epilepsy
Objective: To present the preliminary results of an Italian multicentric study on inherited synaptopathies Background: Inherited synaptopathies are rare genetic disorders characterized by complex and…Proactive Brain Health Alliance Serving Those at Risk for Neurodegenerative Disease
Objective: Research advancements enable earlier identification of neurodegenerative disease risk via prodromal symptoms and genetic and biomarker testing. Those in the “space between” risk and…
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