Tyrosine kinase inhibition clears Tau and reserves neuropathology and motor symptoms in a novel model of progressive supranuclear palsy
Objective: Our objective was to examine the effects of tau accumulation in transgenic mice, observing both motor function and behavior. Background: Tau hyper-phosphorylation is a…Freezing of gait is an early clinical feature of progressive supranuclear palsy
Objective: We attempted to identify any sign or symptom to diagnose progressive supranuclear palsy (PSP) earlier. Background: Early clinical diagnosis of progressive supranuclear palsy PSP…Tau Network Genes in a Genome Wide Association Study of Progressive Supranuclear Palsy
Objective: To determine how tau network genes overlap with single nucleotide polymorphisms (SNPs) associated with Progressive Supranuclear Palsy (PSP) in a Genome Wide Association Study…High throughput pooled-DNA sequencing of mendelian/susceptibility Parkinson’s disease genes in Spanish population
Objective: The primary outcome of our study was the identification of rare variants in 5 major Mendelian PD genes (SNCA, PARK2, PINK1, DJ1, LRRK2) and…Phosphorylation by GSK-3β enhances binding of metal ion induced tau oligomers to neutral lipid surfaces
Objective: To dissect the complex interplay of tau hyperphosphorylation, metal ion induced oligomer formation and membrane interactions applying single particle fluorescence techniques. Background: Fibrillar deposits…THK-5351 tau-tracer uptake in patients with clinically diagnosed progressive supranuclear palsy
Objective: The objective of our study is to investigate characteristics of THK-5351 binding in patients with clinically diagnosed progressive supranuclear palsy (PSP) and correlate tau-tracer…Tau PET in Parkinson syndromes. A new diagnostic tool?
Objective: To explore the potential of [F-18]-AV-1451 PET as a diagnostic tool in Parkinson plus syndromes. Background: Clinically, atypical Parkinson syndromes are often difficult to…[18F]AV-1451 PET imaging of tau in progressive supranuclear palsy and Alzheimer’s disease
Objective: To evaluate: (1) brain tau pathology in vivo in patients with Progressive Supranuclear Palsy (PSP) and Alzheimer's disease (AD); (2) whether brain tau pathology…PET imaging of tau pathology in progressive supranuclear palsy
Objective: This study aimed to determine whether there is an increase in [18F]-AV-1451 uptake in the brains of progressive supranuclear palsy (PSP) patients compared to…Evaluation of the surface based measures to discriminate progressive supranuclear palsy from corticobasal syndrome
Objective: To evaluate structural gray matter (GM) changes tested by surface-based measures of cortical thickness (CTh), surface area (SA) and volume (VOL), in order to…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.