Cell-specific MAPT gene expression is preserved in tau cytopathologies in Progressive Supranuclear Palsy
Objective: To systematically map and quantify MAPT expression in neurons, astrocytes and oligodendroglia across different brain regions to determine whether cell type and/or regional differences…Structural analysis of the basal ganglia using ex vivo 7T MRI can differentiate frontotemporal lobar degeneration with TDP-43 vs tau accumulation.
Objective: Ex vivo 7T MRI can identify macrostructural changes in the basal ganglia that reflect underlying neuropathology, and can be used to differentiate between proteinopathies…18f-PI-2620 tau PET neuroimaging, tau protein burden and 18f-PI-2620 tau autoradiography on human postmortem brain tissue in a PSP patient
Objective: Our aim is to describe the findings of 18F-PI-2620 tau-PET imaging, together with tau protein burden and 18F-PI-2620 tau autoradiography in brain tissue from…Clinico-pathological correlations in atypical parkinsonism
Objective: We aim to assess diagnostic accuracy of the Parkinson-plus syndromes (PPS) using the current consensus criteria, whilst identifying the diagnostically most salient clinical features.…Three patients with PSP presenting with a logopenic pattern of aphasia: expanding the phenotype of language impairment in PSP.
Objective: To investigate the a series of cases presenting with apparent logopenic variant primary progressive aphasia who then developed symptoms suggestive of PSP. Background: Deficits…Neuropathological profile of tauopathy in spinocerebellar ataxia type 8
Objective: The purpose of this study is to examine the distribution of tau pathology in brain regions of patients with spinocerebellar ataxia type 8 (SCA8).…Probable Four-repeat tauopathy criteria in Corticobasal Syndrome: diagnostic accuracy, clinical features and imaging biomarkers
Objective: To compare the “probable four-repeat (4R)-tauopathy” criteria[1] with the clinical research(cr) criteria for corticobasal degeneration (CBD) [2] regarding diagnostic accuracy to predict a negative…Variability in Age of Onset, Age of Diagnosis and Age of Death for Progressive Supranuclear Palsy Patients Among Three Racial Groups in Hawai`i
Objective: To examine if differences in age of symptom onset, age of diagnosis, age of death, and number of years lived after diagnosis exist for…No association between naturally occurring plasma tau autoantibodies and movement disorders
Objective: To determine if there is an association between the presence of naturally occurring plasma tau autoantibodies and a movement disorder diagnosis. Background: The microtubule-associated…CSF biomarkers in neurodegenerative parkinsonism can distinguish between multiple system atrophy and 4-repeat tauopathies, but not between disease with Lewy bodies and multiple system atrophy
Objective: To assess the usefulness of a defined set of blood-based and cerebrospinal fluid-based biomarkers in the differential diagnosis of neurodegenerative proteinopathies. Background: The diagnostic…
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