GABA-A Receptor Positive Allosteric Modulators: Phase 2 Proof of Concept Studies of Brexanolone Injection and SAGE-217 in Essential Tremor
Objective: To examine use of γ-aminobutyric acid (GABA) type A receptor (GABA-A-R) positive allosteric modulators (PAMs) in the treatment of essential tremor (ET) in early…Successful Treatment of Orthostatic Tremor using Perampanel
Objective: Orthostatic tremor is notoriously difficult to treat. To date, there has only been one case report of marked improvement of symptoms using perampanel. We present…DBS Programming In Tremor And Akinetic-Rigid Predominant Parkinson’s Disease
Objective: Deep brain stimulation (DBS) targeting Globus pallidus pars interna (GPi) and subthalamic nucleus (STN) is an established surgical treatment for Parkinson’s disease (PD). Due…The STN Sweet Spot for Tremor Control in Parkinson’s Disease
Objective: Describe 4 cases of Parkinson’s disease (PD) patients with residual tremor post deep brain stimulation of subthalamic nucleus (DBS-STN) that underwent repositioning of electrodes…Is directional stimulation of the VIM superior to omnidirectional stimulation in patients with essential tremor?
Objective: To determine whether directional stimulation of the VIM is superior to omnidirectional stimulation in essential tremor. Background: Deep brain stimulation (DBS) of the VIM…Resting-State fMRI in Essential Tremor after MRgFUS treatment
Objective: Identify network alterations in essential tremor (ET) after magnetic resonance–guided focused ultrasound (MRgFUS) treatment using independent component analysis (ICA). Background: MRgFUS has been approved…The complementary relationship between zonisamide and istradefylline in treating patients with Parkinson’s disease
Objective: To investigate patients with Parkinson’s disease (PD) who received zonisamide and istradefylline at the same period. Background: Zonisamide and istradefylline are anti-PD drugs with…Bio-Electro Stimulation Therapy for the Treatment of Motor and Non-Motor Symptoms in Parkinson’s Disease
Objective: Design an experiment to assess tremor severity comparable to the current clinical standard using Shimmer3 sensors. Investigate collected data to see if BEST intervention…MRI-guided Focused Ultrasound thalamotomy for Multiple Sclerosis-associated tremor: A case report
Objective: To describe the effect of VIM thalamotomy by MRI-guided Focused Ultrasound (MRIgFUS) on Multiple Sclerosis (MS) tremor in a single patient. Background: Tremor is…Effects of MRI-guided Focused Ultrasound unilateral subthalamotomy on characteristics of EMG activity underlying reaction time and tapping test in Parkinson’s disease
Objective: To assess the effect of MRI-guided Focused Ultrasound (MRIgFUS) unilateral subthalamotomy on Parkinson disease’s (PD) motor features through EMG movement analysis. Background: Recent evidence…
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