Why Context Matters: The Influence of Medication and Environment on Real-World Gait in People with Parkinson’s Disease
Objective: To quantify the extent to which contextual factors explain the variability in real-world gait outcomes in people with Parkinson’s disease (PwP) using machine learning…Improvement in Time Spent in OFF State and In the Functional Impact of Motor Fluctuations After Initiation with COMT Inhibitors in Parkinson’s Disease Patients with Early Wearing-Off: Results from the REONPARK Study
Objective: REONPARK study is an observational study conducted in Spain aimed at evaluating COMT inhibitors (iCOMT) tolerability and effectiveness in alleviating motor complications associated with…First Reported Experience of Dual Therapy With Deep Brain Stimulation and Foslevodopa/Foscarbidopa Subcutaneous Infusion
Objective: To describe the first evidence of dual therapy with deep brain stimulation (DBS) and foslevodopa/foscarbidopa (LDp/CDp) subcutaneous infusion treating Parkinson´s disease (PD). Background: In…Clinical Underestimation of Wearing-Off in Parkinson’s Disease: Patient-Reported Outcomes Versus Clinical Assessment and Impact on Quality of Life
Objective: To prospectively investigate the frequency and determinants of wearing-off (WO) in Parkinson's disease (PD) using a validated patient-reported instrument compared to routine neurological evaluation,…Device-aided Therapies are Associated with Significantly Greater Improvement in Quality of Life in Younger Patients Earlier Within Advanced Parkinson’s Disease
Objective: To evaluate the impact on health-related quality of life (HRQoL) of treatment with device-aided therapies (DAT) in younger patients earlier within advanced Parkinson's disease…Dopaminergic Modulation Of Contextual Emotional Appraisal And Shame In Parkinson’s Disease
Objective: To investigate the influence of dopaminergic replacement therapy (DRT) on emotional appraisal and shame-related responses in PD patients with fluctuations. Background: Shame and embarrassment…Perceptions and knowledge about Parkinson’s disease fluctuations among patients and caregivers: insights from a qualitative focus group
Objective: To explore the knowledge, perceptions and experiences of people with Parkinson’s disease and caregivers regarding motor and non-motor fluctuations, identifying informational gaps and training…Real-World Experience with Continuous Subcutaneous Foslevodopa/Foscarbidopa (FLC/FCD) in Advanced Parkinson’s Disease: A Single-Centre Cohort Study
Objective: To evaluate efficacy, safety, and discontinuation rates of FLC/FCD in a retrospective cohort of advanced PD patients. Background: Continuous subcutaneous FLC/FCD is a novel…IPX203 Achieves High Responder Rates Independent of Fluctuation Severity: Insights From RISE‑PD
Objective: To evaluate responder rates for Good ON time and OFF time with IPX203 using PD diary data from the RISE-PD trial, including comparisons by…Seeing the Full Picture: How Subjective and Objective Data Capture the Daily Impact of Fluctuations in Parkinson’s disease.
Objective: To characterize the frequency, phenomenology, subjective relevance, and daily life impact of motor and non-motor fluctuations in a multicenter cohort of Parkinson’s disease (PD)…
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