Session Information
Date: Monday, June 5, 2017
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To define frequency, severity and predictors of dysautonomia in patients with Parkinson’s disease(PD) at the stage of hemiparkinsonism with disease duration less than 2 years.
Background: Autonomic failure may be present at the time of PD diagnosis. Relatively little data is available on specific profile and clinical correlates of dysautonomia in early PD.
Methods: The study comprised 112 PD patients and 79 healthy controls (HC). Autonomic dysfunction was assessed using SCOPA-AUT. Each subject underwent clinical and cognitive evaluation with MDS-UPDRS and ACE-R and screening for depression, anxiety, and apathy.
Results: PD patients had more cardiovascular, gastrointestinal, urinary, genital and thermoregulatory dysfunction compared to HC. Nocturia (37.5%) and impotence (37.9%) followed by constipation (29.46%) were the most frequent symptoms in PD patients. Twenty-two (27.67%) PD patients had one, 21 (18.75%) had two and 19 (16.96%) had three autonomic systems impaired. Total score of autonomic dysfunction correlated to age, total depression, anxiety, apathy scores and LED. No correlation to the UPDRS-motor score and total ACE-R score was found. The multivariate linear regression model was run to predict total SCOPA-AUT score from age, depression, apathy, anxiety and LED. Only age and HDRS score appeared to be statistically significant predictors of higher total scores of autonomic dysfunction. Older age and depression were predictors for gastrointestinal, urinary and sexual dysfunction. Higher motor scores contributed significantly to the sexual dysfunction domain together with depression and age, while higher doses of dopaminergic medications appeared to be the only significant predictor of cardiovascular dysautonomia in the initial motor stage of PD.
Conclusions: In addition to constipation which is well recognized as early autonomic feature of PD, other symptoms of dysautonomia are present in significant number of patients in early disease course. This is longitudinal study and we believe to report the follow-up analysis data soon.
To cite this abstract in AMA style:
I. Stankovic, I. Petrovic, T. Pekmezovic, T. Stojkovic, V. Markovic. Autonomic Dysfunction in Early Parkinson’s Disease: Cross-Sectional Study in Hoehn and Yahr Stage 1 [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/autonomic-dysfunction-in-early-parkinsons-disease-cross-sectional-study-in-hoehn-and-yahr-stage-1/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/autonomic-dysfunction-in-early-parkinsons-disease-cross-sectional-study-in-hoehn-and-yahr-stage-1/