Session Information
Date: Monday, June 5, 2017
Session Title: Surgical Therapy: Parkinson’s Disease
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To investigate the spatial distribution of subthalamic nucleus (STN) beta activity in Parkinson’s disease (PD) recorded from directional deep brain stimulation (DBS) electrodes.
Background: New DBS electrodes able to steer the stimulation field in different directions, entered the marked recently. Previous studies demonstrated that directional DBS has the potential to increase the therapeutic window for improved symptom control in patients with PD. However, this advantage is limited by a substantially increased time needed for clinical contact testing. For the conventional 4-ring electrode lead it has been shown that local field potential (LFP)- beta activity (13-35 Hz) can inform about the contact with high clinical efficacy. Here we explore the LFP spectral beta characteristic from directional DBS electrodes.
Methods: We recorded STN local field potentials in PD patients during DBS surgery using the directional DBS lead (Vercise PC; Boston Scientific, Valencia, CA) after placement in the final position within the DBS target structure. During the recording patients were in a wake and resting state. The beta spectral power density for each stimulation contact was calculated and compared across stimulation contacts.
Results: We found that several subjects with detectable resting beta activity showed differences in its spatial distribution. These differences were evident along the lead axis, but also differentially weighted in the axial direction to specific segmented contacts. The degree of the directional beta localization was variable between subjects.
Conclusions: LFP recording from directional DBS leads seems to indicate direction specific distribution of LFP beta activity and to help localize the main anatomical beta source. Individual differences of beta distribution are partially related to differences in the spatial relationship between contacts and DBS target structure. These spectral differences could inform the clinician about a preferred direction to steer the stimulation field and, thus, to facilitate multicontact lead DBS programming. Further investigations and clinical comparisons are required for the future.
To cite this abstract in AMA style:
G. Tinkhauser, A. Pogosyan, I. Debove, A. Nowacki, H. Tan, K. Petermann, K. Seidel, M. Oertel, C. Pollo, P. Brown, M. Schuepbach. Directional distribution of subthalamic nucleus beta activity in patients with Parkinson’s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/directional-distribution-of-subthalamic-nucleus-beta-activity-in-patients-with-parkinsons-disease/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/directional-distribution-of-subthalamic-nucleus-beta-activity-in-patients-with-parkinsons-disease/