Objective: The objective of this study to compare urine microvesicle between Parkinson’s disease(PD) and healthy controls

Background: Recent researches showed that gut microbiome interact with central nerve system regard to pathogenesis of neurodegenerative disease including PD. In fact, patients with PD showed different gut microbiome from stool compared to control. The purpose of our study is to investigate the microvesicle in urine reflecting gut microbiome in PD.

Methods: Thirty-nine patients with PD and seventy-six age-matched controls were enrolled in our study. We check microvesicle in urine for estimating gastrointestinal microbiome. Microvesicle, which is nano particle derived from gut microbiome, is absorbed through intestinal mucosa and excreted in urine.

Results: In phylum-level, Proteobacteria was markedly decreased (39.93±18.49 vs 18.36±9.86) and Acinobactria was increased in PD group compared to control group (6.74±3.22 vs 14.70±3.17). In genus-level, Ancinetobacter was decreased (6.90±10.54 vs 0.20±0.22) and Bacteroides was increased in PD group compared to control group (4.05±3.09 vs 11.4±2.92).

Conclusions: We found the different proportion of microbiota in urine sample in PD compared to control. These results are accordance with previous report from stool microbiome. Urine can be more easily obtained than stool. Urine microvesicle reflecting gut microbiota may be the candidate for diagnosis tool for differential diagnosis of PD.

« Back to 2017 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/the-comparison-of-urine-microvesicle-reflecting-gut-microbiome-between-parkinsons-disease-and-healthy-control/