Session Information
Date: Saturday, October 6, 2018
Session Title: Clinical Trials and Therapy in Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: The study aims to evaluate the effect of bilateral STN-DBS on levodopa-induced peak-dose dyskinesia in patients with PD.
Background: Dyskinesia is among the most troublesome symptoms of advanced Parkinson’s disease (PD). Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a very effective surgical procedure for PD. It significantly improves cardinal parkinsonian symptoms, and as well as levodopa-induced dyskinesia (LID). However, reduction in dyskinesia with STN-DBS has been attributed to reduction in levodopa equivalent dose.
Methods: In this prospective study, 20 consecutive patients with severe levodopa-induced peak-dose dyskinesia undergoing Bilateral STN-DBS implantation were enrolled. The post-operative medication remain unchanged in the first three months, then reduced gradually. DBS activated within the first week after implantation, the stimulation parameters were carefully screening following of all contacts at the three-month postoperative visit. Patients were examined three times: prior to the DBS implantation (baseline), three months and one year postoperatively. The severity of PD-related symptoms was assessed by the UPDRS.The presence and severity of dyskinesia were specifically measured by the Unified Dyskinesia Rating Scale (UDysRS).
Results: All the patients were dyskinesia-free whether medication reduction or not. High-frequency electrical stimulation dorsal to the STN can directly suppress levodopa-induced dyskinesia.
Conclusions: STN deep brain stimulation can directly suppress levodopa-induced dyskinesia in Parkinson’s disease
References: 1. Genko Oyama, Kelly D. Foote, Charles E. Jacobson IV, Frances Velez-Lago, Criscely Go,Natlada Limotai, Pamela R. Zeilman, Janet Romrell, Samuel S. Wu , Dan Neal, Michael S. OkunGPi and STN deep brain stimulation can suppress dyskinesia in Parkinson’s disease.Parkinsonism and Related Disorders 2012(18): 814-818. 2. Jos e Fidel Baizabal-Carvallo, Joseph Jankovic, Movement disorders induced by deep brain stimulation.Parkinsonism and Related Disorders 2016(25) :1-9. 3. Francesca Del Sorbo, Alberto Albanese. Levodopa-induced dyskinesias and their management.J Neurol (2008) 255 [Suppl 4]:32–41.
To cite this abstract in AMA style:
J. Li, Y. Zhang. STN deep brain stimulation can directly suppress levodopa-induced dyskinesia in Parkinson’s disease [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/stn-deep-brain-stimulation-can-directly-suppress-levodopa-induced-dyskinesia-in-parkinsons-disease/. Accessed June 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/stn-deep-brain-stimulation-can-directly-suppress-levodopa-induced-dyskinesia-in-parkinsons-disease/