Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Neuroimaging and neurophysiology
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To study the dynamic changes of the olfactory cortex function in the early-stage Parkinson’s disease (PD) using functional magnetic resonance imaging (fMRI).
Background: Olfactory dysfunction is a prodromal symptom of PD and prevalent in most PD patients with functional deficits in odor detection, identification, and discrimination. Previous studies have demonstrated functional deficits in the PD patients’ olfactory cortex. However, it is not clear if the functional deficits in the olfactory cortex progress with the disease.
Methods: Twenty-seven early-stage idiopathic PD patients participated in a longitudinal study of 4 visits in 2 years (baseline, 12 mo, 18 mo, and 24 mo). In addition, a group of 20 age- and gender-matched healthy subjects were studied as controls. All subjects gave written informed consent that approved by the institutional review board. The olfactory fMRI was conducted on a scanner with BOLD-sensitive EPI. The odor stimulation paradigm consisted of twelve repetitions of odor-sniffing and odorless-air-sniffing. Lavender oil diluted in 1,2-propanediol at 0.1% (vol/vol) was used as the olfactory stimulant. The fMRI data at the individual level were processed with SPM8. Statistical parametric maps for odor-induced activation were generated by subtracting odorless-air-sniffing activation from odor-sniffing activation. Analysis of longitudinal fMRI data was conducted using Sandwich Estimator for Neuroimaging Longitudinal Data.
Results: Comparing to the healthy controls, odor-induced activation in the PD patients’ olfactory cortex was significantly reduced. Over the two-year course of the disease, the odor-induced activation in the left primary olfactory cortex, left insular cortex, and left hippocampus was significantly reduced.
Conclusions: In the early-stage of PD, there is a significant functional deterioration in the olfactory cortex over time.
To cite this abstract in AMA style:
J. Wang, Z. Mosher, T. Subramanian, Q.X. Yang. A longitudinal study of functional deterioration of primary olfactory cortex in early-stage Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/a-longitudinal-study-of-functional-deterioration-of-primary-olfactory-cortex-in-early-stage-parkinsons-disease/. Accessed May 11, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/a-longitudinal-study-of-functional-deterioration-of-primary-olfactory-cortex-in-early-stage-parkinsons-disease/