Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Psychiatric manifestations
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To record the prevalence and clinical correlates of impulse control disorders (ICDs) in recent onset Parkinson’s disease (PD) cases in the Tracking Parkinson’s (PRoBaND) study.
Background: ICDs including gambling, hypersexuality and compulsive behaviours are increasingly recognized in PD.
Methods: ICDs (Questionnaire for Impulsive Compulsive Disorders in PD), motor severity (Unified Parkinson’s disease Rating Scale Part 3), depression (Leeds Anxiety and Depression Scale>6), anxiety (Leeds Anxiety and Depression Scale >6), personality traits (Big Five Inventory), non-motor symptoms (Non-Motor Symptom Scale), rapid-eye movement sleep behavior disorder (RBD Screening Questionnaire >4), and daytime sleepiness (Epworth Sleepiness Scale>10) were recorded in recent onset PD cases.
Results: In 1987 PD cases, mean age 67.6 years (SD 9.3), 65.7% male, mean disease duration 1.3 years (SD 0.9), hobbyism was the most frequent ICD present in 9.7%, followed by punding (5.5%), compulsive eating (5.4%), hypersexuality (5.3%), compulsive buying (3.7%), gambling (1.6%), medication overuse (1.5%) and walkabout (1.1%). 78.7% of cases had no ICDs, 14.2% one, 4.6% two and 2.6% three or more. Increasing numbers of ICDs were associated with younger age (p<0.001), male sex (p=0.016), longer disease duration (p<0.001) and greater motor severity (p=0.029). Increasing numbers of ICDs were also associated with lower agreeableness (p<0.001) and conscientiousness (p<0.001), and higher neuroticism (p<0.001) and openness (p=0.006) scores. Depression (p=0.006), anxiety (p=0.001), RBD (p<0.001), daytime sleepiness (p<0.001), total non-motor scores (p<0.001), and, more dopamine agonist use (p<0.001) and higher levodopa equivalent daily doses (p<0.001) were also associated with increasing numbers of ICDs.
Conclusions: ICDs affected under a quarter of cases of recent onset PD. A large number of correlates, including personality traits, were associated with the presence of ICDs.
To cite this abstract in AMA style:
D.M.A. Swallow, M.A. Lawton, K.A. Grosset, N. Malek, N. Bajaj, R.A. Barker, Y. Ben-Shlomo, D.J. Burn, T. Foltynie, J. Hardy, H.R. Morris, N. Williams, N.W. Wood, D.G. Grosset, PRoBaND Collaborators. Neuropsychiatric, personality and non-motor correlates of impulse control disorders in recent onset Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/neuropsychiatric-personality-and-non-motor-correlates-of-impulse-control-disorders-in-recent-onset-parkinsons-disease/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/neuropsychiatric-personality-and-non-motor-correlates-of-impulse-control-disorders-in-recent-onset-parkinsons-disease/