Objective: The objective is to compare the prevalence of RBD in the different motor subtypes of Parkinson`s disease (PD), using polysomnography as the gold standard.

Background: One of the ways to classify PD, is according to motor symptoms using the Unified Parkinson´s Disease Rating Scale revised by the MDS (MDS-UPDRS).Three motor subtypes can be identified: 1.- Tremor dominant (TD), 2.- Postural Instability and Gait Disorder (PIGD) and 3.- Undetermined subtype. The three of them share motor and non-motor symptoms, but their frequency may vary in relation to the motor subtype. In previous years, many studies have shown distinct results about the prevalence of probable RBD based on questionnaires and scales, like the Parkinson´s Disease Sleep Scale (PDSS) and the RBD screening questionnaire (RBDSQ).

Method: In this cross-sectional hospital-based study, we evaluated 112 patients with a diagnosis of PD. Patienys were categorized in the different motor subtypes using items of the MDS-UPDRS parts II and III. In addition, all patients underwent a night videopolysomnograph. The diagnosis of RBD was confirmed based on the practice guidelines of the American Academy of Sleep Medicine (AASM).

Results: A total of 53 women (47.3%) and 59 men (52.7%) were included. The mean age was 60 ±11.6 years and mean disease duration was 6.6 ±4.4 years. The TD group included 40 patients, PIGD 63 patients and 9 patients in the Undetermined subtype. RBD was diagnosed in 10 patients in the TD group (25%), in 23 patients in the PIGD group (36.5%) and in 2 patients of the Undetermined subtype (22.2%) (p: 0.39) No significant difference was found between subgroups.

Conclusion: The present study suggest that the presence of RBD diagnosed by polysomnography in the different motor subtypes of PD is similar. Our findings are comparable with previous studies were questionnaires and scales were used for RBD diagnosis.

References: 1.- Jankovic, J et al. Parkinson disease subtypes. JAMA Neurol. 2014;71(4):499-504. doi:10.1001/jamaneurol.2013.6233. 2.- Fereshtehnejad SM et al. New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol 2015 Aug;72(8):863-73 doi:10.1001/jamaneurol.2015.0703. 3.- Zhang, X et al. Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis. Neurol Sci. 2017 Jan;38(1):163-170 doi 10.1007/s10072-016-2744-1.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-of-rem-behavior-disorder-rbd-in-different-motor-subtypes-of-parkinsons-disease-corroborated-by-polisomnography/