Influence of onset age on the progression of non-motor symptoms in Parkinson's disease: A prospective study from Southwest China

R. Ou, B. Cao, Q. Wei, K. Chen, W. Song, J. Yang, B. Zhao, Y. Wu, H. Shang (Chengdu, People's Republic of China)

Meeting: 2016 International Congress

Abstract Number: 271

Keywords: Non-motor Scales, Parkinsonism

Session Information

Date: Monday, June 20, 2016

Session Title: Parkinson's disease: Non-motor symptoms

Session Time: 12:30pm-2:00pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To explore the influence of onset age on the progression of non-motor symptoms (NMS) in Parkinson’s disease.

Background: NMS are gaining increasing relevance in the management of Parkinson’s disease (PD), but little is known about their differences of progression between early-onset PD (EOPD) and late-onset PD (LOPD) patients.

Methods: One hundred and forty-five Chinese patients with PD were included in this study. NMS were assessed using the Non-Motor Symptom Scale (NMSS, 9 domains).

Results: After adjusting for confounding factors, EOPD patients at the last visit had higher frequency of “Urinary” domain and score of “Sleep/fatigue” domain than those who at baseline visit (P < 0.05), while LOPD patients at the last visit had higher frequencies of “Mood/apathy”, “Urinary”, and “Sexual dysfunction” domains and scores of total NMSS, “Attention/memory” and “Urinary” domains than those who at baseline visit (P < 0.05). No significant differences in the annual severity change of each NMS were found between EOPD and LOPD patients. The multinomial logistic regression model indicated that the proportions of “Perceptual problems/hallucinations” and “Urinary” domains increase, and the proportions of “Gastrointestinal” and “Urinary” domains presence in LOPD patients were significantly higher than in EOPD patients (P < 0.05)

Multivariate logistic regression analyses for the relationship between age of onset and NMS presence
			Age of onset
	Groups a	OR	95%CI	P value
Mood/apathy	Decrease	0.500	0.107-2.333	0.378
	Presence	1.677	0.594-4.734	0.329
	Increase	2.833	0.830-9.668	0.096
Perceptual problems/hallucinations	Decrease	0.218	0.046-1.028	0.054
	Presence	0.262	0.054-1.259	0.095
	Increase	0.291	0.092-0.924	0.036*
Gastrointestinal	Decrease	0.635	0.164-2.457	0.511
	Presence	0.122	0.047-0.319	<0.001*
	Increase	0.672	0.260-1.741	0.413
Urinary	Decrease	0.333	0.090-1.231	0.099
	Presence	0.120	0.044-0.330	<0.001*
	Increase	0.331	0.129-0.848	0.021*

NMS: non-motor symptoms. a NMS frequency absence was chosen as reference category.*Significant difference..

Conclusions: Urinary symptoms increase and sleep/fatigue worsen in EOPD patients, while emotional and autonomic symptoms increase along with cognitive and urinary symptoms worsen in LOPD patients as disease advances. Comparing to EOPD patients, psychic, urinary and gastrointestinal symptoms in LOPD patients are pone to turn up or increase as disease advances. The severity evolution of each NMS is not different between EOPD and LOPD patients as disease advances.

To cite this abstract in AMA style:

R. Ou, B. Cao, Q. Wei, K. Chen, W. Song, J. Yang, B. Zhao, Y. Wu, H. Shang. Influence of onset age on the progression of non-motor symptoms in Parkinson’s disease: A prospective study from Southwest China [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/influence-of-onset-age-on-the-progression-of-non-motor-symptoms-in-parkinsons-disease-a-prospective-study-from-southwest-china/. Accessed May 18, 2025.

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