Category: Parkinsonism, Atypical: MSA
Objective: Elevated cortisol levels are found in many diseases, including infectious, related to aging, depression, and associated with a depressive status. Elevated cortisol levels are found in many diseases, including infectious, related to aging, depression, and associated with a depressive status.
Background: We studied the level of morning plasma cortisol in the SecondaryVascular Parkinsonism( SVP) in 72 patients who was hospitalized in Department 1 of TMA neurology in the period 2015 until 27/02/2020. The relationship between increased morning plasma cortisol and cognitive impairment was determined. The results of the study were statistically analyzed. Cortisol was determined in all blood samples of patients of the Main and Control groups. The control group consisted of 43 volunteers.
Method:
The concentration of cortisol was studied by enzyme immunoassay on an automatic analyzer EL 808 Ultra Microplete Rider (BIO-TEC Instruments, Inc) using standard sets of reagents “Steroid IFA-cortisol-01” series No. 061P and “Non-extraction IGF-1 ELISA DSL-10-2800 “. The reference values of the norm of cortisol were 50 – 250 mg / ml. To assess cognitive status, we evaluated on the The Cognitive Failures Questionare( CFQ), MOCA test.
Results: Cortisol levels In the main group 21 (29.1%) was 50 – 250 mg / ml, 39(54.16%) patients 250 – 500 mg / ml, 12 patients (16.7%)500 – 900 mg / ml cortisol levels. Cortisol levels in the control group 29(68%), 8(19.1%), 3(6%).
Spearman’s rank correlation coefficient. The relationship of cortisol levels and indicators of cognitive impairment: in the main group CFQ r=-0.42 p=0.03, MOCA test r=-0.11 p≥0.05.
The relationship between the value of cortisol and the assessment of cognitive impairment was determined. In the main group, a statistically significant moderate inverse correlation was determined between plasma cortisol level and cognitive impairment in SVP. When studying cortisol levels in SVP, its significant increase is noted than in the control (p <0.05).
Conclusion: Increased levels of the hormone cortisol in Parkinson’s disease play an important role in cognitive impairment pathogenesis and during the course of the disease and affect the effectiveness of SVP therapy.
To cite this abstract in AMA style:
D. Akramova. Secondary Vascular Parkinsonism: Role of increasing levels cortisol in the cognitive impairment [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/secondary-vascular-parkinsonism-role-of-increasing-levels-cortisol-in-the-cognitive-impairment/. Accessed May 17, 2025.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/secondary-vascular-parkinsonism-role-of-increasing-levels-cortisol-in-the-cognitive-impairment/