Objective: We aimed to explore which cognitive functions and neuropsychiatric symptoms affect QOL, and are therefore predictive of changes in QOL, before and after DBS surgery.

Background: Indications for deep brain stimulation (DBS) surgery are determined basically by preoperative motor function; however, postoperative quality of life (QOL) is not necessarily correlated with the improvement in motor symptoms, suggesting that cognitive and psychiatric symptoms might affect QOL after surgery in patients with Parkinson’s disease.

Method: ndications for deep brain stimulation (DBS) surgery are determined basically by preoperative motor function; however, postoperative quality of life (QOL) is not necessarily correlated with the improvement in motor symptoms, suggesting that cognitive and psychiatric symptoms might affect QOL after surgery in patients with Parkinson’s disease.

Results: Of the 59 participants, 43 completed the postoperative clinical evaluation after 3 months, 40 after 1 year, and 23 after 3 years. Higher impulsivity scores and higher frontal lobe function led to significantly worse QOL before and 1 year after surgery. Preoperative higher impulsivity scores and greater reductions in the scores on MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III during the “off” phase between before and 3 months after surgery led to significant improvement in QOL 3 months after surgery.

Conclusion: Preoperative higher impulsivity scores and improvement in motor functions led to better QOL 3 months after surgery.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/preoperative-higher-impulsivity-leads-to-better-quality-of-life-after-deep-brain-stimulation-in-parkinsons-disease/