Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To identify which regions are associated with dementia in Parkinson’s disease (PD) brains.
Background: Dementia is common in advanced PD and its early development predicts poor prognosis. Dysfunction of the cerebral cholinergic and the mesolimbic dopaminergic systems may contribute to the development of dementia in PD. Brain magnetic resonance imaging apparent diffusion coefficient (ADC) reflects hydrogen motility and is elevated in degenerated regions.
Methods: In this cross-sectional case-control study, we analyzed the relationship between dementia and ADC in brain regions. PD patients were divided into those with and without dementia. Brain regions where ADC was associated with dementia were identified using a multivariate logistic regression model, and the strength of the association was estimated as odds ratios with adjustment for age, sex, and PD duration and severity (Unified Parkinson’s disease Rating Scale Part III score).
Results: Fifty-three PD patients were assigned with probable dementia and 58 with non-dementia according to the Clinical Diagnostic Criteria for dementia associated with PD. Multivariate logistic regression analysis demonstrated that increased diffusivity in the amygdala and external capsule was significantly associated with dementia (amygdala: P=0.002, external capsule: P=0.036) with adjusted odds ratios of 13.7 (95% confidence interval [CI]: 2.72–68.7), and 4.39 (95% CI: 1.10–17.5), respectively.
Conclusions: In PD patients with dementia, high ADC was noted in the amygdala and the external capsule, constituting the lateral cholinergic pathway, suggesting that these regions are involved in the pathophysiology of dementia of PD.
This study has been presented at the International Congress on Non-Motor Dysfunctions in Parkinson’s disease and Related Disorders in December 7, 2014.
To cite this abstract in AMA style:
A. Umemura, T. Oeda, K. Yamamoto, M. Kohsaka, S. Tomita, K. Park, H. Sugiyama, H. Sawada. Dementia in Parkinson’s disease is associated with increased diffusivity in amygdala and external capsule [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/dementia-in-parkinsons-disease-is-associated-with-increased-diffusivity-in-amygdala-and-external-capsule/. Accessed July 1, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/dementia-in-parkinsons-disease-is-associated-with-increased-diffusivity-in-amygdala-and-external-capsule/