Category: Parkinson’s Disease: Clinical Trials
Objective: We report clinical outcomes associated with the use of Deep Brain Stimulation (DBS) systems capable of directionality and Multiple Independent Current Control (MICC).
Background: Deep Brain Stimulation (DBS) is an established treatment for motor signs and fluctuations associated with Parkinson’s disease (PD). Retrospective studies can provide a relatively quick and cost-effective means to obtain data regarding various types of patient outcomes when devices are being used per standard-of-care in the real-world clinical setting, thereby contributing to real-world evidence (RWE).
Method: This is an international, multi-center observational study of DBS patient outcomes (NCT03664609) based on retrospective chart review. Patients assessed were implanted with a DBS system (Vercise, Boston Scientific) capable of MICC and/or directionality for use in the treatment of motor symptoms of Parkinson’s disease. Data related to disease state, motor function, and overall quality of life are collected. Additionally, reduction in anti-parkinsonian medications usage is also assessed.
Results: Data from 340 patients have been collected (mean age 65.5 ± 9.5 years, 69.5% male, disease duration of 12.9 ± 5.7 years). Of the patient data currently available (N = 119), a significant 6.2-point improvement in PDQ-39 (Quality of Life) was noted at 12-months post-implant. In addition, over 90% clinicians and patients reported improvement in PD symptoms up to 12-months post-implant as measured by Global Impression of Change. Cognitive health as measured by multiple relevant assessment scales (e.g., BDI, MOCA, MMSE) also indicated stable mental status in most patients.
Conclusion: RWE obtained from this multicenter, observational case-series demonstrates improved quality of life, decreased medication intake and overall stable mental/cognitive status in Parkinson’s disease patients at up to 12-months post-implant using a DBS system capable of directionality and Multiple Independent Current Control (MICC).
To cite this abstract in AMA style:
T. Zesiewicz, M. Barbe, S. Paschen, C. Luca, C. Zhao, F. Ponce, J. Durphy, J. Ostrem, N. Tomycz, T. Prell, M. Siddiqui, L. Chen, R. Jain. Real-World Deep Brain Stimulation Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/real-world-deep-brain-stimulation-outcomes-using-dbs-systems-with-directionality-and-multiple-independent-current-control/. Accessed May 9, 2025.« Back to 2022 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/real-world-deep-brain-stimulation-outcomes-using-dbs-systems-with-directionality-and-multiple-independent-current-control/