Category: Parkinson's Disease: Non-Motor Symptoms
Objective: To summarize quality of life outcomes after 2 years of deep brain stimulation (DBS) for Parkinson’s disease (PD).
Background: DBS improves motor fluctuations associated with PD and concurrently improves patient quality of life. We will evaluate the impact of DBS on quality of life in a large real-world observational study.
Method: ADROIT (Abbott DBS Post-Market Study of Outcomes for Indications over Time) is a large, international, prospective, multicenter, post-market, observational study that collects long-term safety and effectiveness data on Abbott DBS systems in the real-world setting. Post-implant follow-up visits occur 6 months after initial programming and annually through 5 years. Quality of life and functional outcome data are collected at baseline and follow-up.
Results: The study has enrolled 633 subjects across 41 sites globally including 355 PD patients newly implanted with an Abbott DBS system with an average of 11 years of symptom duration. At a group level, PDQ-39 summary index improved from 29.6±15.2 (n=324) at baseline to 23.3±14.7 (n=138) at 1 year and 20.9±12.2 (n=52) at 2 years. In paired analyses, PDQ-39 summary index improved by 5.8 points at 1 year and 7.2 points at 2 years. Average EQ-5D VAS scores improved from 57.8±18.8 (n=335) at baseline to 68.1±17.7 (n=147) at 1 year and 70.6±18.0 (n=55) at 2 years. Improvements in patients, clinician, and caregiver global impression of change indices were also reported at these timepoints. Average baseline severity scores were 5.1, 5.0, and 5.2 (marked to severe), respectively, which improved to 3.6, 3.2, and 3.9 (mild to moderate) at 2 years. Global improvement scores were 2.0, 2.1, and 2.2, respectively at 2 years, representing a ‘much improved’ change on average.
Conclusion: Results from a large prospective observational study showed an improvement in multiple indicators of quality of life after DBS in newly implanted patients for PD in a real-world setting. This interim report will summarize 2-year paired data for quality of life assessments after DBS for PD.
To cite this abstract in AMA style:
A. Gharabaghi, L. Lopez, A. Schnitzler, S. Chen, L. Himes, M. Frassica, D. Nanduri, S. Groppa. Interim Report of Quality of Life Outcomes After Deep Brain Stimulation for Parkinson’s Disease from a Large Global Real-World Study [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/interim-report-of-quality-of-life-outcomes-after-deep-brain-stimulation-for-parkinsons-disease-from-a-large-global-real-world-study/. Accessed June 15, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/interim-report-of-quality-of-life-outcomes-after-deep-brain-stimulation-for-parkinsons-disease-from-a-large-global-real-world-study/