Objective: Clinical diagnosis Parkinson’s disease (PD), is often difficult, with the appearance of motor symptoms hence the importance of identify non-invasive early markers is a current challenge in the neurodegeneration field. Insulin-like growth factor 2 (IGF2) and immune response have been proposed as an interesting biomolecule related to Idiopathic PD.

Background: PD is a chronic, progressive and neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra, which causes motor deficits such as bradykinesia, stiffness, tremor, and postural instability, among others. An increase of proinflammatory cytokines in the blood and brain samples has been reported in PD patients. In addition, peripheral blood T cells recognized α-syn, triggering a chronic inflammation in the peripheral and brain tissue in PD. In Chile there are no precise statistics on the prevalence incidence of the disease, but there is an estimate of approximately 40,000 patients throughout the country.

Method: A total of 68 patients with idiopathic PD and 47 healthy controls, with a mean age of 69.6 years were evaluated. We measurement the stage and progression of the disease, time of disease progression, motor complications, sleep disorders and gastrointestinal disorders, and peripheral blood was obtained to determine the levels of the IGF2 and inflammatory markers levels in polymorphonuclear blood cells (PMBCs), from Chilean patients

Results: The results shown, of the 42 Parkinsonian patients examined; 13 had HyY stage 2 with IGF2 levels averaging 0.201; 26 have HyY 3 with IGF2 levels on average of 0.58, and 4 patients whith HyY 4, with IGF2 levels averaging 0.035, compared with controls who with IGF2 levels averaging 1.5, which may indicate that the greater the progression of the disease. Moreover we observed an increase of inflammatory response (IL1 beta; NFkb; IL17) in PBMCs samples from PD patients against health control group. In addition, we found correlations inverse between IGF2 plasma levels and motor symptoms related with the severity of the disease

Conclusion: Furthermore, IGF2, together inflammatory response may be involved in the underlying pathophysiology of PD, and maybe a potential biomarker by this disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/insulin-like-growth-factor-2-and-inflammatory-response-in-parkinson-disease-potential-predictor-marker/