Objective: The goal of the study is to evaluate the significance of oxidative stress in the examination and pathophysiology of Progressive Supranuclear Palsy (PSP). Additionally, authors intended to verify whether the two most common subtypes differ in the context of parameters associated with oxidative stress.

Background: PSP is a disease affected by several pathophysiological pathways among which could be mentioned oxidative stress, neuroinflammation and mitophagy disruption among others. Furthermore, it is not known whether the mechanisms vary depending on the subtype of PSP. PSP-Richardson’s syndrome (PSP-RS) and PSP-Parkinsonism Predominant (PSP-P) are two most common subtypes of the disease. PSP-RS is characterized by a more rapid deterioration, whereas in PSP-P the progress of the disease is more gradual.

Method: In this study authors examined 12 patients with PSP-P, 12 with PSP-RS and 12 controls. The patients were examined using the contemporary clinical diagnosis of PSP. The disease duration among patients with PSP-P and PSP-RS varied between 3 and 6 years. Each had a serum evaluation using thiobarbituric acid reactive substances (TBARS). The levels of TBARS were subsequently analyzed using U-Mann Whitney in the comparisons between PSP-RS and control as well as between PSP-P and controls.

Results: In case of PSP-P the levels of TBARS, interpreted as an oxidative stress indicator, were found to be significantly (p=0,0141) higher than in controls. The comparison between PSP-RS and controls did not reveal significant differences (p=0,2099).

Conclusion: The examination of oxidative stress parameters may be a feasible tool in supplementary examination. Differences observed in TBARS may suggest distinct patomechanisms of PSP subtypes, however more research in the field is required.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/oxidative-stress-in-progressive-supranuclear-palsy/