Objective: For testing the likelihood of decreasing psychiatric dyskinesias of STN-DBS, conducting experimentally and through experimental studies we explore the properties of in what best S T N DB stimulations c a n be advanced.
Background: The STN-DBS affecting the nonmotor cognition plus mood in the Parkinson`s. such effects might overshadow encouraging paraphernalia over motor symptoms. Thus, a most important problem for diseased, kin – kith family. Therefore, seek the best therapy to control the occurrence of undesired psychiatric dyskinesias. Such effects are supposed to be triggered via STN stimuli of non motoric signs, connected by changes in seroto nergic system because high-frequency stimuluses inhibit dorsal-raphe nuclei(DRN) neural-firings plus concentrated proclamation of serotonin within the non-primate animals. Social and axial symptoms also big issue in Parkinson`s.
Method: In this study twenty-six Parkinson patients (2019-2024) recruited for STN-DBS surgery (Table 1). Their experimental outcomes coherent with advanced Parkinson disease (PD) and suffering from terrible fluxes plus side-effects. Microelectrode recording(MER) was done in 1mm steps as of 10mm above the target, plus in 0.5mm stages as of 5mm above the target, up to predictable nigral behavior was envisioned. Stimulations were done and after determining the final target for stimuli, the quadripolar leads were implanted with pole1at the determined optimal position within STN.
Results: Post op phase progression over the UPDRS stage III ( p < 0.01) also stage-IV ( p <0.01) was observed plus 33% decline in levodopa equivalent dose( p < 0.02). Motor progression was worsened because of deterioration of akinesia:12.6±4.8, p<0.032 plus axial(10.0±2.9, p<0.02. The cognition and retention functioning seemed to progress yet the decline amid 1- 3 years following process(p<0.01). However, the feeling continued moderately steadily through supplement. Some spontaneous activities were observed followingsurgery.
Conclusion: Motor progression indicated decline because of the increase in akinetic as well as axial symptoms like speech and freezing of gait(FoG).
Demographics of Parkinson`s
References: 1. Ana Monteiro, Carlos Andrade, Maria J Rosas, Paulo Linhares, João Massano, Rui Vaz, Carolina GarrettDeep brain stimulation of the subthalamic nucleus in advanced Parkinson’s disease: five year follow-up at a Portuguese center, Rev Neurol
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Marcus L F Janssen, Annelien A Duits, Ali H Turaihi, Linda Ackermans, Albert F G Leentjens, Albert F G Leentjes, Vivianne van Kranen-Mastenbroek, Mayke Oosterloo, Veerle Visser-Vandewalle, Yasin TemelSubthalamic nucleus high-frequency stimulation for advanced Parkinson’s disease: motor and neuropsychological outcome after 10 years,Stereotact Funct Neurosurg
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To cite this abstract in AMA style:
A. Dabbeta, V. Rama Raju. Findings of motoric and neuro psychological outcome using high frequency stimulations in Parkinsons with STN-DBS [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/findings-of-motoric-and-neuro-psychological-outcome-using-high-frequency-stimulations-in-parkinsons-with-stn-dbs/. Accessed October 5, 2025.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/findings-of-motoric-and-neuro-psychological-outcome-using-high-frequency-stimulations-in-parkinsons-with-stn-dbs/