Clinical impact of local field potential sensing–guided deep brain stimulation: a real‑world registry
Objective: To evaluate the association between Local Field Potential (LFP) sensing use and patient outcomes (EuroQol 5-Dimensions (EQ5D), medications), as well as device-related outcomes by…An Optimized Workflow for High-Throughput RNA-Seq from Human Deep Brain Tissue Using DBS Microelectrodes
Objective: To optimize a workflow for extracting human deep brain RNA from DBS microelectrodes for transcriptome sequencing. Background: Understanding the molecular mechanisms of Parkinson’s disease…Randomness and bursting of pallidal spiking activity correlates with DBS outcome in Parkinson’s disease and dystonia
Objective: The aim of the current study is to characterize spontaneous pallidal neuronal activity in patients with Pakninson’s disease (PD) and dystonia with different clinical…Findings of motoric and neuro psychological outcome using high frequency stimulations in Parkinsons with STN-DBS
Objective: For testing the likelihood of decreasing psychiatric dyskinesias of STN-DBS, conducting experimentally and through experimental studies we explore the properties of in what best…GBA Mutations Alter Subthalamic and Nigral Neural Activity in Parkinson’s Disease
Objective: To investigate the neurophysiological basis of Parkinson’s disease (PD) in patients with glucocerebrosidase (GBA) mutations. Background: Alterations in subthalamic neural activity are associated with…Synchronized High Frequency Neural Oscillations as a Biomarker for Differentiating the Internal from the External Segment of the Globus Pallidus in Parkinson’s Disease
Objective: To assess whether using high frequency oscillations (HFO; 150-350 Hz) or beta band oscillations (13-30 Hz) can objectively differentiate the external from the internal…Parameterization of Intraoperative Human Microelectrode Recordings: Linking Action Potential Morphology to Brain Anatomy
Objective: To investigate whether single-unit spike morphology from intraoperative microelectrode recordings (MER) can provide anatomical and physiological insights relevant to deep brain stimulation (DBS) targeting.…Optimizing Electrode Placement in STN-DBS for Parkinson’s Disease: The Added Value of Intraoperative Neurophysiological Monitoring
Objective: This study aims to evaluate the role of intraoperative neurophysiological monitoring, specifically microelectrode recording (MER) and test stimulation, in optimizing electrode placement for deep…Relationship Between Cortico-basal ganglia Beta Oscillations and Excessive Daytime Sleepiness in Parkinsonism
Objective: To examine the relationship between beta oscillations in the cortico-basal ganglia circuit and daytime vigilance in parkinsonism. Background: Exaggerated beta oscillations in the cortico-basal…Effectiveness of Lead-Point in Parkinson`s Model of STN-MER with DBS: A Study of Predicting Motor progression
Objective: To inquiry into the correlation between progression and active point of contact site expects an adjustment for functional (anatomical-structural) variation. Background: Within the Parkinson…
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