Objective: To identify the clinical correlation between neurocognitive functioning and depressive symptomatology in patients with IPDWD, assessed by a new scale (ESDEPARK) that measures depression specifically in patients with this type of motor pathology.
Background: Deep brain stimulation (DBS), is a surgical procedure, which aims to improve cardinal motor symptoms in patients diagnosed with Idiopathic Parkinson’s Disease without Dementia (IPDWD). The data obtained by different investigations indicate that the cognitive phenotype correlated with neurobehavioral alterations such as depression, tends to improve months after the intervention by DBS. However, these results are compatible with an adequate treatment by Clinical, Functional and Advanced Neuropsychology that aims to improve the quality of life in patients diagnosed with IPDWD
Method: Method: participants: We recruited 50 patients diagnosed with IPDWD, intervened by DBS, with a mean age of 64.85 years. We determined the association of the cognitive phenotype assessed by the Parkinson’s Disease Rating Scale (PD-CRS), correlated with the ESDEPARK scale to assess depressive symptomatology, and compared it with a group of healthy subjects without a diagnosis of IPDWD. Statistical analysis: The Mann-Whitney U test and Spearman’s Rho were used.
Results: There are significant differences between patients with IPDWD and the group of healthy subjects (p<0.000) in all components of cognitive performance. There are significant differences between both groups in the score obtained in the ESDEPARK (p< 0.001). There is a statistically significant negative correlation between the ESDEPARK total score and the PD-CRS total score (Rho= -,401; p= ,004) and spontaneous clock test (Rho= -,501; p= ,001).
Conclusion: Patients with IPDWD treated by DBS present general deficits in their cognitive phenotype, correlated with clinical pictures of depression in IDPWD. Nevertheless, are more specific in visuospatial and visuoconstructive tasks Treatment by Clinical, Functional and Advanced Neuropsychology will improve cognitive performance in this type of patient.
To cite this abstract in AMA style:
C. Alberto Hurtado-González, J. Felipe Ayala-Rico, S. Ospina-Otalvaro, P. Gutiérrez-Lenis, A. Lucumi Moreno, M. Cañas-Lucendo, D. Reyes-Torres, L. Villegas-Trujillo, S. Ordoñez-Cure, K. Rivera-Quintero. Neurocognitive Functioning and Neurobehavioral Alterations in a Group of Patients Diagnosed with Idiopathic Parkinson’s Disease Without Dementia by Deep Brain Stimulation. Descriptive Study of the ESDEPARK Scale. [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/neurocognitive-functioning-and-neurobehavioral-alterations-in-a-group-of-patients-diagnosed-with-idiopathic-parkinsons-disease-without-dementia-by-deep-brain-stimulation-descriptive-study-of-the-es/. Accessed October 5, 2025.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/neurocognitive-functioning-and-neurobehavioral-alterations-in-a-group-of-patients-diagnosed-with-idiopathic-parkinsons-disease-without-dementia-by-deep-brain-stimulation-descriptive-study-of-the-es/